{"id":"W4394989327","doi":"10.1101/2024.04.19.24306098","title":"Comparative gene regulatory networks modulating <i>APOE</i> expression in microglia and astrocytes","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Instituto de Salud Carlos III; Canadian Institutes of Health Research; Deutsches Zentrum für Neurodegenerative Erkrankungen; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Fondation Brain Canada; Rush University; National Institute of Neurological Disorders and Stroke; Fleni; Alzheimer's Association","keywords":"Biology; Microglia; Apolipoprotein E; Gene; Gene expression; Genetics; Genome-wide association study; Regulation of gene expression; Gene regulatory network; Transcriptome; Single-nucleotide polymorphism; Immunology; Medicine; Disease; Genotype; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001844981,0.0001418161,0.000258032,0.0006367587,0.0002148279,0.0002807565,0.0001313524,0.0001276333,0.001193397],"category_scores_gemma":[0.0003408564,0.0001101694,0.0004230459,0.000494059,0.0002168602,0.00009923634,0.0002098785,0.000171079,0.0002040132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001986955,"about_ca_system_score_gemma":0.0002268765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608272,"about_ca_topic_score_gemma":0.002198958,"domain_scores_codex":[0.9997998,0.00002076028,0.000007820571,0.0001095661,0.00002736151,0.00003465894],"domain_scores_gemma":[0.9997819,0.00007454431,0.00007343943,0.00001628048,0.00002710329,0.00002684186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001245455,0.00005885915,0.1629783,0.0002836162,0.0002774333,0.0002949659,0.0002735859,0.003317824,0.8112407,0.001558946,0.0007817622,0.01768853],"study_design_scores_gemma":[0.0000482368,0.0003349371,0.9111775,0.00005118309,0.0003618992,0.0006532343,0.0003604931,0.01703939,0.06176495,0.002293154,0.005878309,0.00003665105],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903998,0.0005297141,0.003798909,0.0000379315,0.000008295092,0.00001171249,0.004345421,0.00009468961,0.000773508],"genre_scores_gemma":[0.9911329,0.0002654767,0.003677292,0.00006349955,0.000007817624,0.00004806839,0.004032868,0.00003468684,0.0007374445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001608272,"threshold_uncertainty_score":0.003992319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04234296477195736,"score_gpt":0.2787713406888843,"score_spread":0.2364283759169269,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}