{"id":"W4394989339","doi":"10.1101/2024.04.19.590207","title":"Neuronal Autophagy Failure Drives α-Synuclein Transfer to Microglia to Outsource Aggregate Clearance","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trinity College","funders":"Trinity College, University of Cambridge; Association France Parkinson; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Microglia; Autophagy; Neuroscience; Aggregate (composite); Differential (mechanical device); Cell biology; Chemistry; Medicine; Materials science; Inflammation; Nanotechnology; Biology; Immunology; Physics; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002285313,0.0003509965,0.0004127918,0.0001909393,0.0002076889,0.0003602559,0.0001716313,0.0005089243,0.001373371],"category_scores_gemma":[0.0001370795,0.0001269573,0.0002842401,0.0001259563,0.0003353871,0.0001951868,0.0002871636,0.0005781334,0.0006484134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003088264,"about_ca_system_score_gemma":0.0003236265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005024191,"about_ca_topic_score_gemma":0.0006312515,"domain_scores_codex":[0.9997825,0.00003371121,0.00002231139,0.00004835839,0.00005257004,0.00006058622],"domain_scores_gemma":[0.9998833,0.00002300374,0.00003323252,0.00001805456,0.00001297285,0.0000294279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001182397,0.00003006511,0.0001299247,0.00003643249,0.000006457617,0.0002177261,0.00002759469,0.0000866296,0.998172,0.0001988558,0.0001026675,0.0008732911],"study_design_scores_gemma":[0.00002116218,0.0002049706,0.002295067,0.00001489488,0.00001442665,0.0006687088,0.00007370044,0.001506853,0.9929612,0.0002563987,0.001976758,0.000005869982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926103,0.0009137684,0.003132048,0.0002448099,0.00009169887,0.0000442901,0.0004434202,0.000131142,0.002388556],"genre_scores_gemma":[0.9940203,0.0005158291,0.001656617,0.0000944257,0.00001498652,0.00006129087,0.0002660362,0.00004045157,0.00333007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001373371,"threshold_uncertainty_score":0.004594386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01078702815096803,"score_gpt":0.2281997615591976,"score_spread":0.2174127334082296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}