{"id":"W4394989662","doi":"10.1016/j.cbi.2024.111012","title":"Interaction of exogenous acetylcholinesterase and butyrylcholinesterase with amyloid-β plaques in human brain tissue","year":2024,"lang":"en","type":"article","venue":"Chemico-Biological Interactions","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie Medical Research Foundation","keywords":"Butyrylcholinesterase; Acetylcholinesterase; Genetically modified mouse; Human brain; Chemistry; Endogeny; Aché; Enzyme; Biochemistry; Transgene; Endocrinology; Biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004897444,0.0003716403,0.0002775055,0.0002885052,0.0002851355,0.0003681445,0.0003394531,0.0004174514,0.002029554],"category_scores_gemma":[0.0005919464,0.0002259388,0.0004066727,0.0003140284,0.000312589,0.0003037346,0.0002340461,0.0005521383,0.0004801176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149841,"about_ca_system_score_gemma":0.0003149384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002522967,"about_ca_topic_score_gemma":0.001719332,"domain_scores_codex":[0.9996347,0.0001460616,0.0000226299,0.00006827142,0.00004904499,0.00007913342],"domain_scores_gemma":[0.9996911,0.0001708412,0.00002287856,0.00004075472,0.0000463887,0.00002806004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001889955,0.0001669949,0.001492442,0.0001851899,0.00009056924,0.000671893,0.0001914719,0.0001772712,0.9922377,0.0002010747,0.00007867291,0.002616741],"study_design_scores_gemma":[0.0000665774,0.001049148,0.01097726,0.00002275119,0.0001199203,0.0007402528,0.0002259612,0.001616125,0.9833707,0.0001314871,0.001669996,0.000009905062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903532,0.004634241,0.002280552,0.00007147593,0.00004783274,0.00002628868,0.0001270528,0.00001582592,0.002443453],"genre_scores_gemma":[0.9926159,0.001725586,0.00161014,0.00004107168,0.0000296632,0.00003508832,0.0003478655,0.0000127026,0.003581924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002522967,"threshold_uncertainty_score":0.006789565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05524113893500589,"score_gpt":0.3793078676045444,"score_spread":0.3240667286695386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}