{"id":"W4394993718","doi":"10.1038/s41467-024-47815-2","title":"LSD1 drives intestinal epithelial maturation and controls small intestinal immune cell composition independent of microbiota in a murine model","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Princess Margaret Cancer Centre; University Health Network","funders":"Biotechnology and Biological Sciences Research Council; Helse Midt-Norge; Norges Forskningsråd; Faculty of Medicine and Health, University of Sydney; Research Councils UK; Norges Teknisk-Naturvitenskapelige Universitet; Kreftforeningen","keywords":"Immune system; Biology; Composition (language); Cell biology; Immunology; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003282596,0.0004049973,0.000283028,0.0007564134,0.000296828,0.000468768,0.0003493392,0.0006270255,0.00187766],"category_scores_gemma":[0.0001591231,0.0003652699,0.0003728642,0.0001683189,0.0006632439,0.0003399714,0.0003788284,0.00129834,0.0005057065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006736285,"about_ca_system_score_gemma":0.0004073261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005773886,"about_ca_topic_score_gemma":0.00130628,"domain_scores_codex":[0.9997036,0.00005465451,0.00002706322,0.00007479553,0.00006175686,0.00007817624],"domain_scores_gemma":[0.9996208,0.00003164615,0.0001312471,0.00005588043,0.00001795451,0.0001425162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005404512,0.0001244243,0.0005107955,0.00004044837,0.000005950502,0.0001228226,0.00003949296,0.0001622945,0.9967828,0.0003442537,0.00009684135,0.001229421],"study_design_scores_gemma":[0.0001856162,0.001886897,0.008298384,0.00003521203,0.0000343789,0.0007564546,0.0001190129,0.003015875,0.9801994,0.0003009702,0.005150815,0.00001694617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943216,0.000819132,0.002580005,0.0002466521,0.00003232131,0.00004953214,0.0006270344,0.0002078194,0.001115893],"genre_scores_gemma":[0.9921341,0.0004712838,0.002279996,0.00009636168,0.00001151182,0.00007173008,0.0004370686,0.00004919585,0.00444879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00187766,"threshold_uncertainty_score":0.006281435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377525178736558,"score_gpt":0.250775571920934,"score_spread":0.2370003201335684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}