{"id":"W4394994802","doi":"10.1523/jneurosci.1709-23.2024","title":"Inhibitory Roles of<i>Apolipoprotein E</i>Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Korea Health Industry Development Institute; Japan Agency for Medical Research and Development; Fondation Brain Canada; Japan Society for the Promotion of Science; Deutsches Zentrum für Neurodegenerative Erkrankungen; National Institute on Aging; Alzheimer's Association; Ministry of Education, Culture, Sports, Science and Technology; Fleni; Eisai","keywords":"Induced pluripotent stem cell; Neuroscience; Stem cell; Biology; Cell biology; Genetics; Embryonic stem cell; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002184028,0.0003464559,0.0001750298,0.0001986394,0.0002002403,0.0002380766,0.0002663382,0.0003945862,0.001030076],"category_scores_gemma":[0.00009581153,0.0001010239,0.0003046662,0.0001230772,0.0002704258,0.0001626187,0.0002337919,0.0005664085,0.0002622256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002070501,"about_ca_system_score_gemma":0.0004596765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002550146,"about_ca_topic_score_gemma":0.005405142,"domain_scores_codex":[0.9998142,0.00002566202,0.00002405855,0.00003127698,0.00006472643,0.00004012438],"domain_scores_gemma":[0.9999042,0.00001135432,0.00002583963,0.00001392893,0.00001809536,0.0000266113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002263387,0.00008522556,0.0002571428,0.00006857641,0.000007338336,0.0001864367,0.00003193126,0.00009257705,0.9965629,0.0002202198,0.00007441862,0.002186828],"study_design_scores_gemma":[0.00002697021,0.0006733557,0.003149878,0.00001289895,0.00002730729,0.0002665759,0.00005842329,0.0005542413,0.9933817,0.00008224262,0.001760302,0.000006071472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912282,0.001573617,0.003647448,0.0001590485,0.00008064393,0.0001168043,0.0003600597,0.00009940044,0.002734759],"genre_scores_gemma":[0.9905241,0.001803777,0.003772222,0.0001078062,0.00001536035,0.0001189328,0.0003878672,0.00002485577,0.003245082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002550146,"threshold_uncertainty_score":0.005070567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0570534803295623,"score_gpt":0.3223189062007727,"score_spread":0.2652654258712104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}