{"id":"W4394997547","doi":"10.1016/j.plrev.2024.04.008","title":"The interplay between inflammatory mediators and mechanotransduction is mediated by ion channels in articular chondrocytes: Functional consequences in osteoarthritis","year":2024,"lang":"en","type":"review","venue":"Physics of Life Reviews","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"HORIZON EUROPE Framework Programme; Lietuvos Mokslo Taryba; Magyar Tudományos Akadémia; Academy of Finland; Oulun Yliopisto; European Cooperation in Science and Technology; European Commission","keywords":"Mechanotransduction; Osteoarthritis; Neuroscience; Ion channel; Articular cartilage; Cell biology; Chemistry; Medicine; Psychology; Biology; Internal medicine; Pathology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005883662,0.0009310694,0.001377559,0.001213753,0.0001964891,0.001190996,0.0008702928,0.00118511,0.002990202],"category_scores_gemma":[0.0007265236,0.0002242485,0.0003898344,0.001810717,0.0004874241,0.001155241,0.0007946062,0.00182326,0.002043494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005599353,"about_ca_system_score_gemma":0.001066907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009728353,"about_ca_topic_score_gemma":0.001833589,"domain_scores_codex":[0.9998272,0.00001971587,0.00002132624,0.00002801193,0.00008261244,0.0000212033],"domain_scores_gemma":[0.9997059,0.0001150709,0.00004100624,0.000007756482,0.00009239367,0.00003793507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000147862,0.00004545421,0.0001451717,0.0126651,0.00009475168,0.0001564313,0.00004045345,0.0004121293,0.004924183,0.004127836,0.05781269,0.919428],"study_design_scores_gemma":[0.00003224006,0.00008063063,0.0009775549,0.002302845,0.0001385387,0.0005198313,0.00005420574,0.000102883,0.0006647779,0.002795508,0.9923085,0.00002258705],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007079805,0.9987784,0.000132581,0.0002691747,0.0003259649,0.000001930802,0.00001705828,0.000006464184,0.0003976732],"genre_scores_gemma":[0.0003718439,0.9984764,0.0001240057,0.0001686639,0.000315575,0.000003153623,0.00002412822,0.000001249397,0.0005148901],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002990202,"threshold_uncertainty_score":0.01000327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03166946893704026,"score_gpt":0.3049710632101231,"score_spread":0.2733015942730829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}