{"id":"W4395007984","doi":"10.1111/acps.13692","title":"Phenotypic clustering of bipolar disorder supports stratification by lithium responsiveness over diagnostic subtypes","year":2024,"lang":"en","type":"article","venue":"Acta Psychiatrica Scandinavica","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders; University of Toronto; McGill University Health Centre; Dalhousie University","funders":"Research Nova Scotia; Canadian Institutes of Health Research; Dalhousie University; Dalhousie Medical Research Foundation","keywords":"Bipolar disorder; Lithium (medication); Mood; Internal medicine; Mood stabilizer; Demographics; Phenotype; Population stratification; Bipolar I disorder; Medicine; Family history; Clinical psychology; Psychology; Psychiatry; Biology; Genotype; Genetics; Demography; Mania; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000954703,0.0002536309,0.0003749109,0.0009094761,0.0005930589,0.0007993818,0.00025574,0.0003716045,0.001717616],"category_scores_gemma":[0.005724417,0.0001537332,0.0003461727,0.0005544139,0.0004157925,0.0003334412,0.0008646481,0.0003181676,0.0004077776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002724739,"about_ca_system_score_gemma":0.0003121107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001945736,"about_ca_topic_score_gemma":0.002274691,"domain_scores_codex":[0.9990396,0.0004286568,0.0001135516,0.0001705222,0.0001500793,0.00009767207],"domain_scores_gemma":[0.997403,0.0007300283,0.001038653,0.0002976939,0.000327129,0.0002034286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005549444,0.00003324412,0.9851272,0.00003649339,0.0001170354,0.0001431656,0.0005143677,0.0003817869,0.003057679,0.0001129931,0.0002820731,0.009639089],"study_design_scores_gemma":[0.00001214483,0.00008402896,0.9974159,0.00001318372,0.00003366832,0.0003688723,0.0003120304,0.001106197,0.0002052044,0.0002608661,0.0001811391,0.000006800833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988362,0.00009159264,0.0003943532,0.00005120745,0.000003506276,0.00001194034,0.0001408356,0.000007189754,0.0004631698],"genre_scores_gemma":[0.999281,0.00002194069,0.0003102001,0.00001054581,0.00000716481,0.000007575208,0.0003211288,0.000002360046,0.00003812287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001945736,"threshold_uncertainty_score":0.005746007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007521989243710198,"score_gpt":0.2711936498031643,"score_spread":0.2636716605594541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}