{"id":"W4395009911","doi":"10.3390/cancers16081600","title":"Signaling by Type I Interferons in Immune Cells: Disease Consequences","year":2024,"lang":"en","type":"article","venue":"Cancers","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; Canada Research Chairs; University Health Network","funders":"National Cancer Institute; National Institutes of Health","keywords":"Immune system; Tumor microenvironment; Cancer research; Interferon; Signal transduction; Tumor progression; Biology; Cancer; Immunology; Cancer cell; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001385935,0.0001161523,0.0001607028,0.0001544391,0.00002874991,0.00002267951,0.0001488646,0.00008122824,0.001228586],"category_scores_gemma":[0.00003838468,0.0001047192,0.00004855564,0.0002014472,0.000242566,0.00007432011,0.00003125685,0.000274679,0.0004745164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004815461,"about_ca_system_score_gemma":0.0005173059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007829086,"about_ca_topic_score_gemma":0.00007918434,"domain_scores_codex":[0.9991505,0.0001263714,0.0002184723,0.0002205526,0.00001627634,0.0002678767],"domain_scores_gemma":[0.9997124,0.0001159091,0.00001950948,0.0001213851,0.00001350495,0.00001726592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005755716,0.00001103576,0.0001505897,0.00003669177,0.00003797072,0.00005697115,0.0005688731,0.00009523476,0.9894289,0.0003054953,0.007282116,0.001450515],"study_design_scores_gemma":[0.0006021697,0.0002042451,0.0002976728,0.0007831326,0.00002017232,0.00001167571,0.001216896,0.00009932325,0.8610146,0.0001328265,0.1353411,0.0002761752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8679355,0.1279723,0.00001842611,0.0004013245,0.002389188,0.0001275853,0.00003937604,0.00005964556,0.001056622],"genre_scores_gemma":[0.9938793,0.0007567408,0.000003660308,0.0001337239,0.000009709545,0.00002079687,0.00003049917,0.00001269418,0.005152835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1284143,"threshold_uncertainty_score":0.9996845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376948333833853,"score_gpt":0.2641355772435333,"score_spread":0.2503660939051948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}