{"id":"W4395011567","doi":"10.3390/pharmaceutics16040563","title":"Modulating the Nature of Ionizable Lipids and Number of Layers in Hyaluronan-Decorated Lipid Nanoparticles for In Vitro Delivery of RNAi","year":2024,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"In vitro; Transfection; Gene silencing; RNA interference; Nanoparticle; Chemistry; Luciferase; Gene delivery; Double layer (biology); Biophysics; Nanotechnology; Rational design; Layer (electronics); RNA; Gene; Biochemistry; Materials science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119452,0.00008179445,0.0001339014,0.00004102489,0.00001248652,0.000006988842,0.0001026254,0.00009748064,0.000005285272],"category_scores_gemma":[0.00003849795,0.00006560495,0.00004511674,0.0001498678,0.00006899767,0.000006755796,0.00006257845,0.0001092248,3.809973e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007081019,"about_ca_system_score_gemma":0.00005353304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003371914,"about_ca_topic_score_gemma":0.00002005119,"domain_scores_codex":[0.9993595,0.00003723022,0.0002618812,0.0001469844,0.00006487574,0.0001295529],"domain_scores_gemma":[0.9996783,0.00005287951,0.00006142879,0.0001068128,0.00008135161,0.00001920998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002119748,0.00004382387,0.006278998,0.0001822093,0.00004305886,8.331729e-7,0.0001648335,0.0005982781,0.9863709,0.00003538593,0.0001019579,0.005967699],"study_design_scores_gemma":[0.0003824607,0.0000759947,0.0005245661,0.00007460795,0.00002565055,0.000002965872,0.0001547542,0.01952272,0.9781724,0.00008668079,0.0009115243,0.00006568982],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958585,0.00363527,0.00003500134,0.00007792529,0.0001376681,0.0001423419,0.00004441342,0.000002536731,0.00006635669],"genre_scores_gemma":[0.9989136,0.0005474641,0.00034471,0.00007286543,0.00004519115,0.00000951609,0.00001635297,0.0000108787,0.0000393869],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01892444,"threshold_uncertainty_score":0.2675292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184500965950136,"score_gpt":0.3272365348038137,"score_spread":0.3053915251443123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}