{"id":"W4395026096","doi":"10.1016/j.clim.2024.110154","title":"212 Human ASXL1 Deficiency Causes Epigenetic Dysfunction, Combined Immunodeficiency and EBV–Associated Hodgkin Lymphoma","year":2024,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Lymphoma; Immunodeficiency; Epigenetics; Hodgkin lymphoma; Medicine; Immunology; Cancer research; Severe combined immunodeficiency; Virology; Biology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000131779,0.0004405897,0.0002031155,0.0006052321,0.0002130362,0.0002502571,0.0001831845,0.0004729994,0.00288258],"category_scores_gemma":[0.0002061652,0.0001749774,0.0001526255,0.0002670937,0.0003986295,0.0001592304,0.0002393226,0.0002523861,0.0003168454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001730052,"about_ca_system_score_gemma":0.0001478819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004598358,"about_ca_topic_score_gemma":0.0003757793,"domain_scores_codex":[0.9998823,0.00002514112,0.00001803264,0.00002681224,0.00002231511,0.0000253537],"domain_scores_gemma":[0.9998715,0.00004150856,0.00003037115,0.00001398694,0.00000931584,0.00003324639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001752788,0.0002604736,0.02944985,0.0001557736,0.00009922877,0.07384763,0.00024538,0.0004528041,0.8778466,0.001102242,0.0008006421,0.01398667],"study_design_scores_gemma":[0.000388209,0.001572561,0.2080812,0.00006591358,0.0003696333,0.3035252,0.0006697281,0.003921946,0.4631864,0.001722576,0.01643899,0.00005753769],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971253,0.0003336839,0.000538811,0.00007958384,0.00002004402,0.0000110802,0.0002034193,0.00004176081,0.001646357],"genre_scores_gemma":[0.9986411,0.0001258252,0.0002335363,0.00003179883,0.000008738085,0.000004248267,0.0001252032,0.000006485152,0.0008232359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00288258,"threshold_uncertainty_score":0.009643137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0241599388927717,"score_gpt":0.3046034705345206,"score_spread":0.280443531641749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}