{"id":"W4395028698","doi":"10.1021/acsnano.3c06225","title":"Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center; Division of Electrical, Communications and Cyber Systems; International Institute for Nanotechnology, Northwestern University; Materials Research Science and Engineering Center, Harvard University; Vanderbilt University Medical Center; Division of Materials Research; Vanderbilt University; Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University; Division of Graduate Education; Northwestern University; Pharmaceutical Research and Manufacturers of America Foundation; U.S. Department of Veterans Affairs; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Canadian Institutes of Health Research; National Science Foundation","keywords":"Agonist; Retinoic acid; Cancer immunotherapy; Immunotherapy; Cancer; Gene; Cancer research; Chemistry; Computational biology; Biology; Biochemistry; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001454151,0.0003197811,0.0001712941,0.0002179663,0.0001099695,0.0002742287,0.0001882894,0.0004883101,0.002041173],"category_scores_gemma":[0.00008293169,0.0001610831,0.0002042742,0.0001152842,0.0001226438,0.0002598949,0.0002151877,0.0004463413,0.0009884909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392989,"about_ca_system_score_gemma":0.0001824732,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002644892,"about_ca_topic_score_gemma":0.0004622483,"domain_scores_codex":[0.9999013,0.00001331607,0.000004656018,0.00002867153,0.00003859133,0.00001344808],"domain_scores_gemma":[0.9999644,0.000006930828,0.00001101167,0.000003989951,0.000007776028,0.000005950023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002578621,0.000006958278,0.00001927587,0.00003435737,0.000001981138,0.00001686554,0.000005542425,0.0001352665,0.9965389,0.000129776,0.0002154199,0.002869854],"study_design_scores_gemma":[0.00001256788,0.0001291542,0.0002364987,0.000008748145,0.0000078667,0.0001337611,0.000008930552,0.003708337,0.9866099,0.0001163323,0.00902156,0.000006411386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7454335,0.02113788,0.1880063,0.001693123,0.000475078,0.0003775204,0.001612906,0.003072253,0.03819143],"genre_scores_gemma":[0.8915516,0.006362468,0.07944006,0.0004845878,0.00005469867,0.000311674,0.001031603,0.0001822717,0.02058101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002041173,"threshold_uncertainty_score":0.006828368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917700045933285,"score_gpt":0.2843554603848251,"score_spread":0.2651784599254923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}