{"id":"W4395028698","doi":"10.1021/acsnano.3c06225","title":"Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"ACS Nano","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Congressionally Directed Medical Research Programs; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center; Division of Electrical, Communications and Cyber Systems; International Institute for Nanotechnology, Northwestern University; Materials Research Science and Engineering Center, Harvard University; Vanderbilt University Medical Center; Division of Materials Research; Vanderbilt University; Vanderbilt Institute of Nanoscale Science and Engineering, Vanderbilt University; Division of Graduate Education; Northwestern University; Pharmaceutical Research and Manufacturers of America Foundation; U.S. Department of Veterans Affairs; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Canadian Institutes of Health Research; National Science Foundation","keywords":"Agonist; Retinoic acid; Cancer immunotherapy; Immunotherapy; Cancer; Gene; Cancer research; Chemistry; Computational biology; Biology; Biochemistry; Receptor; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004005307,0.0002582632,0.000306473,0.0001351383,0.0003375818,0.0001034442,0.0003336055,0.0002687162,0.0007120005],"category_scores_gemma":[0.00004718387,0.0002190893,0.0002055184,0.0002956715,0.0001905161,0.0001894051,0.0000455464,0.0002156889,0.0005607076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008973922,"about_ca_system_score_gemma":0.0002502146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001546527,"about_ca_topic_score_gemma":0.00001254955,"domain_scores_codex":[0.9984192,0.000145083,0.0003572898,0.0004382961,0.00004282571,0.0005973644],"domain_scores_gemma":[0.9991339,0.0002234129,0.00006362105,0.0004858086,0.00007579252,0.00001748193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008007754,0.00007793117,0.00007203141,0.00003475789,0.0004272952,0.000004603811,0.0006388218,0.00000192946,0.9464273,0.0009444079,0.008957015,0.04161306],"study_design_scores_gemma":[0.0007607566,0.000195431,0.0001522271,0.00004655334,0.00002706547,0.00003518751,0.00004551591,0.00000344936,0.5735524,0.0001471066,0.4248638,0.0001706147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7996772,0.1944934,0.0002457333,0.001441499,0.002926545,0.0004591955,0.00008568395,0.0004716155,0.000199155],"genre_scores_gemma":[0.9729977,0.003383334,0.0001343281,0.0006549073,0.0001092409,0.000382054,0.00006697675,0.000104883,0.02216653],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4159067,"threshold_uncertainty_score":0.8934201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01917700045933285,"score_gpt":0.2843554603848251,"score_spread":0.2651784599254923,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}