{"id":"W4395034793","doi":"10.1161/circ.144.suppl_1.9386","title":"Abstract 9386: Marfan Syndrome Mouse Model MgΔ <sup>Lpn</sup> Presents Alterations in Glomerular Architecture and Increased Renal Vascular Resistance. Losartan Treatment Attenuates These Phenotypes","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Losartan; Marfan syndrome; Phenotype; Vascular resistance; Internal medicine; Endocrinology; Pharmacology; Pathology; Angiotensin II; Gene; Receptor; Genetics; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002715362,0.001069561,0.0005775919,0.001305178,0.000383444,0.0003764939,0.000417853,0.001052968,0.008104088],"category_scores_gemma":[0.0001323222,0.0003873262,0.0005567629,0.0003251183,0.0006142816,0.0004535527,0.0003080046,0.001682698,0.001767732],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137267,"about_ca_system_score_gemma":0.0002791678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008919414,"about_ca_topic_score_gemma":0.001202791,"domain_scores_codex":[0.9995264,0.00005407844,0.00005963834,0.0001420429,0.0001511699,0.00006661945],"domain_scores_gemma":[0.9996761,0.00001802502,0.0001301555,0.00003072757,0.00002768304,0.0001174265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005463595,0.0001848692,0.0006242478,0.0000993919,0.0000189251,0.0004085301,0.0000478618,0.00006259853,0.9955889,0.0002104416,0.0004053776,0.001802489],"study_design_scores_gemma":[0.0002928908,0.002238458,0.03170475,0.0001073685,0.0001405748,0.007278728,0.0002260758,0.001806728,0.9405112,0.0003716428,0.01527657,0.00004511257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795033,0.001616096,0.007987197,0.0007369686,0.000184098,0.0001335448,0.004817469,0.0008426681,0.004178659],"genre_scores_gemma":[0.9524298,0.001945749,0.01043726,0.0004664525,0.0001004694,0.0005981009,0.005709786,0.0002887505,0.02802354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008104088,"threshold_uncertainty_score":0.02711087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01564209898737959,"score_gpt":0.2639471111457599,"score_spread":0.2483050121583803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}