{"id":"W4395034817","doi":"10.1161/circ.144.suppl_1.9398","title":"Abstract 9398: Dantrolene Prevents Doxorubicin-Induced Cardiac Ryanodine Receptor Dyssynchrony","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Medicine; Dantrolene; Ryanodine receptor; Ryanodine receptor 2; Malignant hyperthermia; Cardiology; Internal medicine; Pharmacology; Receptor; Anesthesia; Calcium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306609,0.0005668406,0.000732797,0.0004090821,0.0001967651,0.0002771473,0.0004223245,0.0004698712,0.004837784],"category_scores_gemma":[0.0001363623,0.0001745898,0.00032158,0.0001481138,0.0003362407,0.0003467452,0.0001968093,0.001325513,0.0008588716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002201141,"about_ca_system_score_gemma":0.0003779846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004112535,"about_ca_topic_score_gemma":0.0007268082,"domain_scores_codex":[0.9998782,0.00001468986,0.00001698375,0.00002949737,0.00002918699,0.00003151523],"domain_scores_gemma":[0.9998759,0.000009913687,0.00004576158,0.00001549779,0.00001285598,0.00003997056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007150106,0.001831454,0.0004515602,0.0002714445,0.00003725727,0.0001268075,0.00003339067,0.0001756422,0.9713976,0.0001982664,0.000851956,0.01747437],"study_design_scores_gemma":[0.002977057,0.02579294,0.01236313,0.0001088272,0.0001691138,0.0005592986,0.0001012916,0.00191836,0.9466498,0.0002195188,0.009107871,0.00003267842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98947,0.002488756,0.001937839,0.0004422586,0.000223498,0.0001894292,0.001950219,0.0004340273,0.002863933],"genre_scores_gemma":[0.9822173,0.002258248,0.003263139,0.0002580254,0.00005403964,0.000457732,0.002096923,0.00007038794,0.009324195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004837784,"threshold_uncertainty_score":0.01618397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02756879547446147,"score_gpt":0.314156174230067,"score_spread":0.2865873787556056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}