{"id":"W4395036449","doi":"10.1161/circ.144.suppl_1.14257","title":"Abstract 14257: Ribosome-Profiling Reveals Translational Control of SND1 as a Determinant of Endothelial Homeostasis in a hiPSC Model of Sunitinib-Induced Vascular Dysfunction","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Sunitinib; Homeostasis; Ribosome profiling; Profiling (computer programming); Internal medicine; Cardiology; Ribosome; Genetics; RNA; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001544657,0.0002660029,0.0003327955,0.0003141575,0.0002072619,0.0002625278,0.0001831518,0.0002602063,0.001607367],"category_scores_gemma":[0.00007904648,0.0001055153,0.0002722247,0.0002235284,0.0002723342,0.0001149076,0.0001851994,0.0005124307,0.0004939177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003576315,"about_ca_system_score_gemma":0.000254177,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007150702,"about_ca_topic_score_gemma":0.001052082,"domain_scores_codex":[0.9998255,0.00001596646,0.0000179405,0.00004918383,0.00005844033,0.00003294924],"domain_scores_gemma":[0.9998801,0.00001586336,0.00004181944,0.00001408908,0.00001439218,0.00003366426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009575597,0.00001537409,0.00008297238,0.00001589599,0.000002408662,0.00003582534,0.000006855916,0.00002804678,0.9992368,0.00004148719,0.00002685892,0.0004116668],"study_design_scores_gemma":[0.00001075867,0.0001957527,0.004203157,0.000003397993,0.000009816174,0.0001365299,0.00001721759,0.0008718093,0.9935301,0.00002528106,0.0009923817,0.000003667354],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884762,0.0009550315,0.006459054,0.0001173,0.0000549617,0.00003480254,0.002125223,0.0001649976,0.001612486],"genre_scores_gemma":[0.9851216,0.000600893,0.006025454,0.00008943102,0.00001452023,0.0000759977,0.003161838,0.00006955482,0.004840617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001607367,"threshold_uncertainty_score":0.005377173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02363272191762547,"score_gpt":0.2597288807172404,"score_spread":0.2360961587996149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}