{"id":"W4395037041","doi":"10.1161/circ.138.suppl_1.16647","title":"Abstract 16647: Loss of Reversibility in Flow-Induced Pulmonary Arterial Hypertension is Associated With a Senescent Vascular Phenotype and Can Be Rescued by Targeted Senolysis","year":2018,"lang":"en","type":"article","venue":"Circulation","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Berger (Canada)","funders":"","keywords":"Medicine; Phenotype; Pulmonary hypertension; Cardiology; Pathophysiology of hypertension; Internal medicine; Blood pressure; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861821,0.0004012128,0.0004147664,0.0004064305,0.0001658177,0.0002819892,0.0002181674,0.0003831319,0.006807168],"category_scores_gemma":[0.0001138211,0.0001534539,0.0004041387,0.0001597665,0.0003256841,0.0002552353,0.0002145937,0.001085366,0.001238383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267439,"about_ca_system_score_gemma":0.0001920991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001790222,"about_ca_topic_score_gemma":0.0001670117,"domain_scores_codex":[0.999849,0.00001924384,0.00001947315,0.0000314928,0.0000376762,0.0000432015],"domain_scores_gemma":[0.9998161,0.00001566026,0.00005484624,0.00002425437,0.00001395981,0.00007527024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005288273,0.0001520343,0.0002911947,0.00006132988,0.00001104719,0.0002087477,0.0000139349,0.00002498015,0.9961235,0.0001447848,0.0001438472,0.002295806],"study_design_scores_gemma":[0.0001188388,0.003126724,0.01375448,0.00002554263,0.00005203655,0.00189962,0.00005658122,0.0006454808,0.9756595,0.0001769924,0.004472203,0.000012092],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925289,0.001678281,0.002543819,0.0001954193,0.0001259392,0.00004879435,0.0008545817,0.0002320804,0.001792322],"genre_scores_gemma":[0.9888201,0.001206417,0.0009619964,0.0001116627,0.0000417906,0.00009492417,0.001274512,0.000060486,0.007428066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006807168,"threshold_uncertainty_score":0.02277225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605591069326207,"score_gpt":0.2555367625260407,"score_spread":0.2294808518327786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}