{"id":"W4395038612","doi":"10.1186/s40364-024-00592-y","title":"Immune escape of multiple myeloma cells results from low miR29b and the ensuing epigenetic silencing of proteasome genes","year":2024,"lang":"en","type":"article","venue":"Biomarker Research","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Associazione Italiana per la Ricerca sul Cancro; Massachusetts General Hospital","keywords":"PI3K/AKT/mTOR pathway; CD28; Gene silencing; Monoclonal gammopathy of undetermined significance; Cancer research; Transfection; MAPK/ERK pathway; Molecular biology; Downregulation and upregulation; CD8; CD80; Multiple myeloma; Cell biology; Biology; Chemistry; Cytotoxic T cell; Immune system; Signal transduction; Cell culture; CD40; In vitro; Immunology; Antibody; Monoclonal antibody; Monoclonal; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008320307,0.0001804201,0.0001770187,0.0001125521,0.0001114844,0.0002428345,0.00009372499,0.0001634092,0.001563641],"category_scores_gemma":[0.00006565357,0.0001046078,0.0002039583,0.00009433892,0.0001160984,0.00008397954,0.0001709306,0.0003794759,0.0005721601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122461,"about_ca_system_score_gemma":0.0001307859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003213651,"about_ca_topic_score_gemma":0.0004258935,"domain_scores_codex":[0.9999156,0.00001039064,0.000007034824,0.00002168073,0.00002916988,0.00001613646],"domain_scores_gemma":[0.9999499,0.000004797068,0.00001984241,0.000006540638,0.000005440882,0.00001340941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006095397,0.000009775355,0.0003474719,0.00001375953,0.000003814502,0.00002523357,0.000003868479,0.00002427687,0.9986595,0.00005505204,0.0000360223,0.0007602492],"study_design_scores_gemma":[0.00001585856,0.0001802403,0.01937104,0.000005123297,0.00001269844,0.0004020394,0.00002667824,0.0007711442,0.97562,0.00008504339,0.003507085,0.000003074789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894568,0.003048187,0.004925163,0.0001613112,0.00003038279,0.00002316978,0.0005619099,0.0001329176,0.001660203],"genre_scores_gemma":[0.9960336,0.0005145238,0.001259042,0.00004685647,0.000005654565,0.00001987611,0.0003743459,0.00001300745,0.001733032],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563641,"threshold_uncertainty_score":0.005230904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06248834702139504,"score_gpt":0.3488840983327582,"score_spread":0.2863957513113631,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}