{"id":"W4395039339","doi":"10.1161/circ.128.suppl_22.a19146","title":"Abstract 19146: Disruption of TRAF2-TAK1-IKKB Signaling Triggers Mitochondrial Perturbations and Necrotic Cell Death in Doxorubicin Cardiotoxicity","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Cardiotoxicity; Medicine; TRAF2; Doxorubicin; Programmed cell death; Apoptosis; Cancer research; Pharmacology; Cell biology; Tumor necrosis factor alpha; Internal medicine; Chemotherapy; Tumor necrosis factor receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680807,0.0004935628,0.0003680484,0.0001952572,0.0002089201,0.0002843523,0.0002349368,0.0004760312,0.006469436],"category_scores_gemma":[0.00009328638,0.0001993372,0.0003310889,0.0001595843,0.0002719484,0.0002713167,0.0002252032,0.0008793427,0.001810699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000271846,"about_ca_system_score_gemma":0.0002000535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003341843,"about_ca_topic_score_gemma":0.0003140506,"domain_scores_codex":[0.99983,0.00003262731,0.00002593682,0.00002874456,0.00003950975,0.00004311712],"domain_scores_gemma":[0.9999031,0.0000118589,0.00002784665,0.000009461371,0.000007377903,0.00004032575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003850116,0.00006141819,0.00005642148,0.00006376786,0.000007075209,0.0001473721,0.00001081577,0.00004225758,0.9983553,0.0001067265,0.0001424073,0.0006214015],"study_design_scores_gemma":[0.0001182232,0.001038955,0.003671859,0.0000269188,0.00002370583,0.00103232,0.00003693067,0.0006057167,0.9885538,0.00007985253,0.004805134,0.000006656684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831337,0.004089163,0.004043354,0.0006027692,0.0003398936,0.000111203,0.002218312,0.0002285887,0.005233003],"genre_scores_gemma":[0.9831444,0.001953477,0.001908664,0.0002220097,0.00005473013,0.0001209812,0.001898145,0.00004333004,0.0106543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006469436,"threshold_uncertainty_score":0.02164239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01402235474623161,"score_gpt":0.2257937778420203,"score_spread":0.2117714230957887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}