{"id":"W4395039859","doi":"10.1161/circ.134.suppl_1.12183","title":"Abstract 12183: <i>SLCO1B1</i> Genotype-Guided Statin Therapy Lowers LDL Cholesterol in Patients With Statin-Intolerance- A Randomized Controlled Trial","year":2016,"lang":"en","type":"article","venue":"Circulation","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dillon Consulting","funders":"","keywords":"Medicine; Statin; Randomized controlled trial; SLCO1B1; Ldl cholesterol; Internal medicine; Ezetimibe; Cholesterol; Cardiology; Pharmacogenetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001599729,0.001181502,0.003583585,0.0003599107,0.0004505659,0.001188987,0.0007620364,0.002463883,0.01053874],"category_scores_gemma":[0.002251867,0.0005035196,0.002740668,0.0005245871,0.0008991058,0.0008393575,0.0003974809,0.002103861,0.001190933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005930586,"about_ca_system_score_gemma":0.0007585902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00100952,"about_ca_topic_score_gemma":0.001666919,"domain_scores_codex":[0.9989902,0.0005399655,0.0001253234,0.0001787874,0.00005562529,0.0001101281],"domain_scores_gemma":[0.9988348,0.000364305,0.0003400667,0.00008155049,0.0001070159,0.0002722013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.985163,0.002315635,0.0008790853,0.001367901,0.002623618,0.00003199701,0.00002638851,0.00007691966,0.0007102158,0.00006218145,0.0008644414,0.005878611],"study_design_scores_gemma":[0.9776354,0.01768492,0.002069493,0.0001017605,0.001855933,0.0000161582,0.00001300138,0.0001647214,0.00006909107,0.00008285735,0.0002980705,0.000008586923],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567043,0.01955824,0.0009269012,0.002917459,0.002414654,0.00978551,0.002757357,0.0002344346,0.004701338],"genre_scores_gemma":[0.9791993,0.004337661,0.00135112,0.002754417,0.001259494,0.007036407,0.001372485,0.00001768655,0.002671307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01053874,"threshold_uncertainty_score":0.03525567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01315618977415413,"score_gpt":0.2539983811563151,"score_spread":0.2408421913821609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}