{"id":"W4395043331","doi":"10.1161/circ.120.suppl_18.s1154","title":"Abstract 5812: A Novel Role of Insulin Degrading Enzyme (IDE) in Atherosclerosis: Studies Using IDE <sup>−/−</sup> Bone Marrow-Derived Cells Show Increased Lesion Development in a Bone Marrow Transplant LDL Receptor <sup>−/−</sup> Mouse Model","year":2009,"lang":"en","type":"article","venue":"Circulation","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Heart Institute","funders":"","keywords":"Bone marrow; Medicine; Insulin-degrading enzyme; Enzyme; Bone marrow transplantation; Insulin; Pathology; Internal medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002190112,0.0008599566,0.0005539355,0.0004032295,0.0001809582,0.0003962749,0.0003556686,0.0005592851,0.00273079],"category_scores_gemma":[0.00007952272,0.0002467367,0.0003974985,0.0001950773,0.0002898205,0.0002310484,0.0001997619,0.001117689,0.001229446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992468,"about_ca_system_score_gemma":0.0001841143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002177798,"about_ca_topic_score_gemma":0.0003051862,"domain_scores_codex":[0.9998065,0.00002479925,0.00002499871,0.00004334319,0.00006134807,0.00003899858],"domain_scores_gemma":[0.9998455,0.00001376037,0.00004456565,0.00001314607,0.00001576867,0.00006726851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002283553,0.00005924382,0.0001331926,0.00003154203,0.000004072057,0.00006446452,0.000004104088,0.000007145633,0.9988691,0.0000326766,0.00003903064,0.0005270021],"study_design_scores_gemma":[0.00009118475,0.001431858,0.007455951,0.00001776891,0.00004146052,0.001082991,0.00003058338,0.0002581862,0.9859725,0.00005213777,0.003558155,0.000007134081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886636,0.002662043,0.004810471,0.0004457097,0.0001522603,0.0000661353,0.001113194,0.0001415451,0.00194497],"genre_scores_gemma":[0.9691738,0.003403327,0.008388506,0.0003313235,0.0001091358,0.0001715147,0.004000937,0.0001176289,0.01430376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00273079,"threshold_uncertainty_score":0.009135365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261124411958077,"score_gpt":0.2396359110171478,"score_spread":0.2135234698213402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}