{"id":"W4395047858","doi":"10.1101/2024.04.21.24306136","title":"Validation of the BOADICEA Model in a Prospective Cohort of <i>BRCA1/2</i> Pathogenic Variant Carriers","year":2024,"lang":"en","type":"preprint","venue":"medRxiv","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIHR Cambridge Biomedical Research Centre; Institut National Du Cancer; Fondation de France; Radboud Universitair Medisch Centrum; Deutsche Krebshilfe; Fondation ARC pour la Recherche sur le Cancer; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Vrije Universiteit Amsterdam; Erasmus Medisch Centrum; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Universiteit Maastricht; Canadian Institutes of Health Research; Direction Générale de l’offre de Soins; Radboud Universiteit; Maastricht Universitair Medisch Centrum; European Commission; Universiteit van Amsterdam; Leids Universitair Medisch Centrum; Universiteit Leiden; Cancer Research UK; Narodowe Centrum Badań i Rozwoju; Rijksuniversiteit Groningen; Amsterdam University Medical Centers","keywords":"Cohort; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01539321,0.001273279,0.001050043,0.001236026,0.0005609636,0.001392096,0.001482756,0.0006555098,0.002131351],"category_scores_gemma":[0.01949445,0.0003772833,0.001736472,0.0005882986,0.0005047799,0.000570151,0.00166737,0.001293436,0.0005600917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008273181,"about_ca_system_score_gemma":0.001510567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01677389,"about_ca_topic_score_gemma":0.00904666,"domain_scores_codex":[0.9963284,0.002486377,0.0001247194,0.0006695177,0.0002047935,0.0001861968],"domain_scores_gemma":[0.9899536,0.007226582,0.0005251297,0.0008822887,0.001000773,0.0004116863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002656118,0.0003522111,0.8097211,0.0001276013,0.002172963,0.0001947464,0.0002448741,0.1445435,0.001031492,0.0005485064,0.001297215,0.03710971],"study_design_scores_gemma":[0.000183215,0.0009100781,0.1511868,0.0001188849,0.0005586269,0.0003353748,0.0002434544,0.8427454,0.0009966544,0.001393083,0.001271379,0.00005705715],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772513,0.0005671708,0.0202438,0.0001937796,0.00004820096,0.00006654588,0.0008043683,0.0001793685,0.0006453943],"genre_scores_gemma":[0.9949619,0.00007022823,0.003798605,0.00003703744,0.0000113381,0.00004121841,0.0008354572,0.00001854261,0.0002257371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01677389,"threshold_uncertainty_score":0.08140808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01000317819295165,"score_gpt":0.2584277434840208,"score_spread":0.2484245652910692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}