{"id":"W4395049682","doi":"10.1172/jci.insight.173205","title":"CETP inhibition enhances monocyte activation and bacterial clearance and reduces streptococcus pneumonia–associated mortality in mice","year":2024,"lang":"en","type":"article","venue":"JCI Insight","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Paul's Hospital","funders":"Providence Health Care Research Institute; Canadian Institutes of Health Research; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Monocyte; Pneumonia; Streptococcus pneumoniae; Streptococcus; Microbiology; Chemistry; Bacterial pneumonia; Medicine; Immunology; Internal medicine; Biology; Bacteria; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009777776,0.0001255355,0.0002139051,0.0000938683,0.00004344627,0.00007744079,0.00001375567,0.00009156048,0.0000349256],"category_scores_gemma":[0.00004974405,0.0001023239,0.00002919036,0.0001730385,0.00004495301,0.0002393918,0.00001847503,0.000108672,0.000005948245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001111793,"about_ca_system_score_gemma":0.00003805568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001986747,"about_ca_topic_score_gemma":0.0001425567,"domain_scores_codex":[0.9991823,0.00004449651,0.0002065224,0.0003114982,0.0001253231,0.0001298172],"domain_scores_gemma":[0.9997087,0.00008191914,0.00005103458,0.00007580261,0.00002723877,0.00005532185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002517308,0.0006038087,0.06317718,0.0001961436,0.000216151,0.0001161896,0.002534759,0.000001751945,0.9116883,0.0002047618,0.0003235537,0.02068572],"study_design_scores_gemma":[0.0006816946,0.0001586373,0.625872,0.0005043233,0.0000515662,0.000002975921,0.00007389448,0.0001105943,0.3716681,0.00009732052,0.0007001486,0.00007874956],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968652,0.001124999,0.000001387784,0.0008342713,0.0001703938,0.0003872557,0.0000117632,0.00005825965,0.0005465029],"genre_scores_gemma":[0.998503,0.001063664,0.00002150418,0.00008371525,0.0001214653,0.00008292178,0.00005809919,0.00001254931,0.00005305461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5626948,"threshold_uncertainty_score":0.4172649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05954676368615246,"score_gpt":0.3346089848837883,"score_spread":0.2750622211976358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}