{"id":"W4395051371","doi":"10.1093/brain/awae127","title":"Leptin receptor reactivation restores brain function in early-life <i>Lepr</i>-deficient mice","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Universidade Federal do Rio de Janeiro; Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Queen's University; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leptin; Leptin receptor; Endocrinology; Neurogenesis; Internal medicine; Atrophy; Melanocortin; Memory impairment; Biology; Receptor; Medicine; Obesity; Neuroscience; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003333728,0.001091387,0.0007837677,0.001225235,0.0003508892,0.0007674544,0.0007829622,0.001022627,0.003051606],"category_scores_gemma":[0.0002446199,0.0005025037,0.0007207614,0.0003304437,0.0009458979,0.0005965551,0.0004981461,0.002364425,0.001392256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004956146,"about_ca_system_score_gemma":0.0005146018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047833,"about_ca_topic_score_gemma":0.001463031,"domain_scores_codex":[0.9996175,0.00004428707,0.00006546079,0.0000942283,0.0000740625,0.0001044735],"domain_scores_gemma":[0.9993421,0.00005587679,0.0002669455,0.00005252995,0.00003348168,0.0002489805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004675128,0.0001185102,0.00008066368,0.00004788161,0.00001588076,0.0001989808,0.0000329983,0.00007077685,0.997306,0.0002291364,0.00006705851,0.001364627],"study_design_scores_gemma":[0.0002134479,0.001010475,0.003415089,0.00005296636,0.00006127424,0.0007914758,0.0001329912,0.000999655,0.9888629,0.0002944494,0.004133245,0.00003200829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878048,0.0025626,0.00437252,0.0004440496,0.000226405,0.0000685668,0.001715649,0.000716924,0.002088451],"genre_scores_gemma":[0.9679915,0.0036823,0.008827983,0.0003252298,0.00009305398,0.0002568766,0.002411969,0.0006527987,0.01575835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003051606,"threshold_uncertainty_score":0.01020867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605991671916286,"score_gpt":0.2626037881280948,"score_spread":0.236543871408932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}