{"id":"W4395051371","doi":"10.1093/brain/awae127","title":"Leptin receptor reactivation restores brain function in early-life <i>Lepr</i>-deficient mice","year":2024,"lang":"en","type":"article","venue":"Brain","topic":"Regulation of Appetite and Obesity","field":"Neuroscience","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research; Universidade Federal do Rio de Janeiro; Instituto Nacional de Ciência e Tecnologia de Neurociência Translacional; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Queen's University; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leptin; Leptin receptor; Endocrinology; Neurogenesis; Internal medicine; Atrophy; Melanocortin; Memory impairment; Biology; Receptor; Medicine; Obesity; Neuroscience; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005659127,0.0001448292,0.0001283205,0.0002810389,0.0001245898,0.0001566775,0.0001498099,0.0001057834,0.0001612492],"category_scores_gemma":[0.001402066,0.0001413024,0.00006684394,0.0007648773,0.00006540554,0.0004497622,0.00004911616,0.0002286502,0.0006824365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001088361,"about_ca_system_score_gemma":0.00008168474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001427203,"about_ca_topic_score_gemma":0.00005930076,"domain_scores_codex":[0.9983022,0.0002237239,0.0002897937,0.0005546061,0.0003725945,0.0002571288],"domain_scores_gemma":[0.9989076,0.0006832608,0.00006553135,0.0002367676,0.00002297824,0.00008388417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001006883,0.00006851356,0.0008640871,0.000031974,0.000002200258,0.000009420465,0.0008062209,0.0001751771,0.9194964,0.01279656,0.05906218,0.006586572],"study_design_scores_gemma":[0.000524488,0.0001968575,0.1419805,0.0002002731,0.000005694189,0.000007285839,0.0001673902,0.002101151,0.2324146,0.001716776,0.6203266,0.0003583636],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9783732,0.00007649879,0.0006774048,0.01540422,0.0006566691,0.000266805,0.000009725983,0.0002338647,0.004301561],"genre_scores_gemma":[0.9901606,0.00001369836,0.00008806521,0.003441336,0.0002490758,0.00002172266,0.00001373313,0.00002639318,0.005985346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6870818,"threshold_uncertainty_score":0.8771569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605991671916286,"score_gpt":0.2626037881280948,"score_spread":0.236543871408932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}