{"id":"W4395059893","doi":"10.1161/circ.132.suppl_3.12040","title":"Abstract 12040: JAK-STAT Signalling and the Atrial Fibrillation-Promoting Fibrotic Substrate: Pathogenic Role and Possible Therapeutic Target","year":2015,"lang":"en","type":"article","venue":"Circulation","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"","keywords":"Medicine; Atrial fibrillation; stat; Signalling; Internal medicine; Signal transduction; Cancer research; Pharmacology; Cell biology; STAT3","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001711503,0.0006818339,0.0004664561,0.0002435262,0.0001988355,0.0007411661,0.0002403056,0.0007020422,0.01187436],"category_scores_gemma":[0.0000658838,0.000143637,0.0002831568,0.0002969172,0.0002964852,0.0003387087,0.0002768911,0.001427208,0.002871274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002806693,"about_ca_system_score_gemma":0.0003569159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002155647,"about_ca_topic_score_gemma":0.0004067562,"domain_scores_codex":[0.9999212,0.00001042289,0.000006781498,0.0000141643,0.0000238238,0.00002362357],"domain_scores_gemma":[0.9999534,0.000004567642,0.00001266999,0.000001696676,0.00000771889,0.00001994691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.006402895,0.0006730413,0.001965584,0.004276306,0.000145418,0.001291289,0.0001296073,0.0004217589,0.8248639,0.004159503,0.02217128,0.1334994],"study_design_scores_gemma":[0.002311981,0.01157411,0.05277354,0.001370305,0.0008419233,0.01065691,0.000618637,0.004019726,0.5001019,0.007470094,0.4081278,0.0001330972],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4166404,0.493896,0.007168401,0.01529706,0.005662545,0.0002929844,0.006243414,0.001077089,0.05372214],"genre_scores_gemma":[0.7874345,0.1327304,0.003480467,0.003077253,0.002736067,0.0001738775,0.005944671,0.00007511801,0.06434757],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01187436,"threshold_uncertainty_score":0.03972363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126116583563318,"score_gpt":0.2275394183493187,"score_spread":0.2062782525136855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}