{"id":"W4395068470","doi":"10.1002/adma.202400307","title":"Tumor‐Tailored Ionizable Lipid Nanoparticles Facilitate IL‐12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto","funders":"Canadian Institutes of Health Research; Connaught Fund; Leslie Dan Faculty of Pharmacy, University of Toronto; Canada Excellence Research Chairs, Government of Canada; J.P. Bickell Foundation; Natural Sciences and Engineering Research Council of Canada; Princess Margaret Cancer Foundation","keywords":"Materials science; Immunotherapy; Lung cancer; Cancer immunotherapy; Cancer; Nanoparticle; Lung tumor; RNA; Nanotechnology; Cancer research; Medicine; Oncology; Biochemistry; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008730988,0.0002405449,0.0001318917,0.0001131687,0.00008548098,0.0002145952,0.0001246773,0.0002847622,0.001027856],"category_scores_gemma":[0.00006763886,0.0001071687,0.0001428912,0.00007853781,0.0001340086,0.0001581247,0.000211871,0.0002891909,0.0004911565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002136743,"about_ca_system_score_gemma":0.0001534763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922871,"about_ca_topic_score_gemma":0.0003772489,"domain_scores_codex":[0.999948,0.00000693963,0.000002953069,0.00001265548,0.000014644,0.00001477212],"domain_scores_gemma":[0.9999653,0.000006128315,0.00001253383,0.000002488821,0.000006390588,0.000007112632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003588462,0.00001285132,0.00003275041,0.00002968849,0.000001663596,0.00002122192,0.000007660859,0.00025529,0.9981633,0.00009375193,0.00006871996,0.001277221],"study_design_scores_gemma":[0.00001578779,0.0001252194,0.0002788302,0.000003106805,0.00000532744,0.00004043215,0.000007685691,0.003031346,0.9948108,0.00003692591,0.001640442,0.000004056588],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717705,0.001519045,0.02119897,0.0002570118,0.00005480793,0.0001132448,0.0002274177,0.0003558217,0.004503055],"genre_scores_gemma":[0.9902201,0.0004252764,0.007049446,0.00007872294,0.00000803203,0.00005085436,0.00008463123,0.00002725841,0.002055742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001027856,"threshold_uncertainty_score":0.003438532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052252079201459,"score_gpt":0.2718301858450828,"score_spread":0.2613076650530682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}