{"id":"W4395084379","doi":"10.1016/j.nbd.2024.106514","title":"RNA sequencing of olfactory bulb in Parkinson's disease reveals gene alterations associated with olfactory dysfunction","year":2024,"lang":"en","type":"article","venue":"Neurobiology of Disease","topic":"Olfactory and Sensory Function Studies","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Aging; Canadian Institutes of Health Research; Arizona Biomedical Research Commission; Arizona Department of Health Services; Michael J. Fox Foundation for Parkinson's Research","keywords":"Olfactory bulb; Biology; Olfactory system; Parkinson's disease; Transcriptome; Olfactory receptor; Neuroscience; Gene expression; Genetics; Gene; Internal medicine; Central nervous system; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001649473,0.0002420761,0.0003524892,0.0003109679,0.000132762,0.00001786707,0.0001420646,0.00007361376,0.0001122718],"category_scores_gemma":[0.001020516,0.0002031542,0.0001355452,0.0004414009,0.0004309471,0.0002569849,0.00005046094,0.0002635343,0.0000156581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009912407,"about_ca_system_score_gemma":0.0002640976,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007246877,"about_ca_topic_score_gemma":0.00001423004,"domain_scores_codex":[0.9978621,0.0005568187,0.0004594021,0.0006232706,0.0002028557,0.0002955713],"domain_scores_gemma":[0.9985163,0.0006978661,0.0001931007,0.0003125391,0.00008027862,0.000199979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009071232,0.0003226035,0.09417642,0.0002458311,0.00005940737,0.0001140571,0.0004041282,0.002124527,0.9003986,0.0005260025,0.0005702719,0.0001510368],"study_design_scores_gemma":[0.001191668,0.000610581,0.8755867,0.0004065483,0.0002684151,0.000003215357,0.000131144,0.0006392387,0.1180503,0.0006242886,0.001953204,0.0005346952],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974635,0.0002438211,0.00006323566,0.0002511397,0.0007982947,0.0003193117,0.0005153677,0.0001266469,0.000218703],"genre_scores_gemma":[0.9989589,0.00009424293,0.0000072988,0.000368378,0.00006073783,0.00003509336,0.00004244877,0.0000269674,0.0004059595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7823483,"threshold_uncertainty_score":0.8284389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1053457037639988,"score_gpt":0.2583877034073587,"score_spread":0.1530419996433598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}