{"id":"W4395111491","doi":"10.1016/j.jtha.2024.04.006","title":"RNA therapeutics to control fibrinolysis: review on applications in biology and medicine","year":2024,"lang":"en","type":"review","venue":"Journal of Thrombosis and Haemostasis","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Fibrinolysis; RNA; Small interfering RNA; Gene knockdown; RNA interference; Plasminogen activator; Coagulation; Hemostasis; Messenger RNA; Biology; Cell biology; Chemistry; Medicine; Gene; Biochemistry; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007734335,0.001219847,0.002170966,0.001917842,0.0002427473,0.001108208,0.001131299,0.001331541,0.004171445],"category_scores_gemma":[0.0008741532,0.0003298856,0.0007115568,0.001846925,0.0004586719,0.00104644,0.0006690712,0.002376058,0.002469291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005606921,"about_ca_system_score_gemma":0.0009079354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007104807,"about_ca_topic_score_gemma":0.001536859,"domain_scores_codex":[0.9997682,0.00003711106,0.00002920572,0.00003648894,0.0001031968,0.00002575508],"domain_scores_gemma":[0.999693,0.0001796993,0.00003300878,0.000009273335,0.00006029779,0.00002468015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001393045,0.0001087412,0.00006806942,0.01779141,0.0001370774,0.0001810394,0.00003636509,0.0005260634,0.00550996,0.003916964,0.04889493,0.9226902],"study_design_scores_gemma":[0.00006484564,0.0001843277,0.0003475766,0.003025532,0.0002154144,0.0006453898,0.00002615607,0.0001631586,0.001222823,0.00185322,0.992224,0.00002748317],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008049752,0.9980718,0.0003313467,0.0002011455,0.0004056092,0.000009591822,0.00002547641,0.00001459504,0.0008599153],"genre_scores_gemma":[0.000448498,0.9978193,0.0003826075,0.0002950773,0.0002199394,0.00001270277,0.0000418614,0.000003308704,0.0007765726],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004171445,"threshold_uncertainty_score":0.01395482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09375740248179006,"score_gpt":0.4386682726539707,"score_spread":0.3449108701721807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}