{"id":"W4395450028","doi":"10.1053/j.gastro.2024.04.020","title":"Basket, Umbrella, and Platform Trials: The Potential for Master Protocol–Based Trials in Inflammatory Bowel Disease","year":2024,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Inflammatory bowel disease; Medicine; Protocol (science); Clinical trial; Disease; Intensive care medicine; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007985016,0.0002412296,0.0007707974,0.000178307,0.00009427513,0.00006933726,0.0002046803,0.0002690078,0.0004683569],"category_scores_gemma":[0.001148178,0.000137322,0.0003878699,0.0000586159,0.0003858847,0.00006307998,0.00009147781,0.0003637603,0.00001963611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002668174,"about_ca_system_score_gemma":0.00007573701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004728073,"about_ca_topic_score_gemma":0.00002618668,"domain_scores_codex":[0.9957675,0.002157882,0.001069038,0.0004442851,0.00003983907,0.0005214185],"domain_scores_gemma":[0.9976366,0.001848669,0.0001771929,0.0002486063,0.00003159708,0.00005737769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2414107,0.002002499,0.157354,0.0050699,0.004690531,0.0006110243,0.0006474326,0.0002265098,0.2185647,0.01137289,0.1866517,0.1713981],"study_design_scores_gemma":[0.05233594,0.006844234,0.1770694,0.0008885833,0.002477782,0.0002640359,0.0003523574,0.01303488,0.00759723,0.01456394,0.7235357,0.001036008],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5685892,0.007230102,0.1140574,0.07106569,0.009570053,0.2266869,0.001909066,0.0005231457,0.0003684643],"genre_scores_gemma":[0.9137079,0.00004396918,0.002590276,0.007827125,0.0007427606,0.07297537,0.0001208716,0.00008820744,0.001903482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.536884,"threshold_uncertainty_score":0.5599831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07373650700413996,"score_gpt":0.3538731137210565,"score_spread":0.2801366067169165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}