{"id":"W4395464376","doi":"10.1093/nar/gkae281","title":"Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; Pfizer Foundation; Joint Programming Initiative on Antimicrobial Resistance; Agence Nationale de la Recherche; Pfizer","keywords":"CRISPR; Biology; Klebsiella pneumoniae; Antimicrobial; Computational biology; Nuclease; Guide RNA; Microbiology; Genome editing; Cas9; DNA; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004900637,0.0004131778,0.0005239492,0.0002844775,0.0001942752,0.0005409201,0.0002471445,0.0004627112,0.0005204637],"category_scores_gemma":[0.0009164447,0.0002027044,0.0003875193,0.0003523167,0.0003126432,0.0002433326,0.0003150393,0.0005018789,0.0003370291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004522215,"about_ca_system_score_gemma":0.0004334941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001473479,"about_ca_topic_score_gemma":0.003079551,"domain_scores_codex":[0.9992204,0.0001112142,0.0001258909,0.0001609954,0.0002806715,0.0001008658],"domain_scores_gemma":[0.9994844,0.0001271273,0.0001887212,0.00007175066,0.00008479333,0.00004311924],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005506824,0.00001861074,0.001045391,0.00005918579,0.00001194829,0.00003010871,0.00001498173,0.0002989548,0.9960167,0.00003225658,0.00003281721,0.002383872],"study_design_scores_gemma":[0.000002789429,0.0003079371,0.008807919,0.00001045853,0.00002917783,0.0002753547,0.00005194219,0.001392309,0.9877082,0.00003380671,0.001363313,0.00001678822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901017,0.001158791,0.006437542,0.00008232556,0.00001457385,0.00004912683,0.0009238654,0.0002178355,0.001014395],"genre_scores_gemma":[0.9880647,0.0005349991,0.009476612,0.00007825191,0.000002766393,0.00003738907,0.0009665043,0.00007191004,0.0007670597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001473479,"threshold_uncertainty_score":0.003281116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578124102375419,"score_gpt":0.3518000232484164,"score_spread":0.3360187822246622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}