{"id":"W4395464376","doi":"10.1093/nar/gkae281","title":"Systematic interrogation of CRISPR antimicrobials in <i>Klebsiella pneumoniae</i> reveals nuclease-, guide- and strain-dependent features influencing antimicrobial activity","year":2024,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"H2020 European Research Council; Pfizer Foundation; Joint Programming Initiative on Antimicrobial Resistance; Agence Nationale de la Recherche; Pfizer","keywords":"CRISPR; Biology; Klebsiella pneumoniae; Antimicrobial; Computational biology; Nuclease; Guide RNA; Microbiology; Genome editing; Cas9; DNA; Genetics; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001585084,0.0001846488,0.000322547,0.000285533,0.00006760642,0.0001222816,0.0002496453,0.0002160081,0.00001354931],"category_scores_gemma":[0.0002475426,0.0001772952,0.00008264566,0.0002866801,0.0001321833,0.00001653478,0.0002854111,0.0003549483,0.00000901328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007596242,"about_ca_system_score_gemma":0.0001299089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001392301,"about_ca_topic_score_gemma":0.0001123663,"domain_scores_codex":[0.9981176,0.0002594955,0.0004307031,0.0004795877,0.0003112957,0.0004013367],"domain_scores_gemma":[0.9992568,0.00009383271,0.00005208906,0.0003714856,0.0001387295,0.00008698451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003507092,0.00003698876,0.0004084549,0.004939072,0.0000545088,0.00002260426,0.0005118594,0.0002101959,0.9920768,0.00005272466,0.00100124,0.0006504817],"study_design_scores_gemma":[0.0003689636,0.0002081046,0.00494318,0.003408679,0.00002647941,0.0001198464,0.0005573385,0.0005028567,0.9893646,0.00003825208,0.0002175409,0.0002441283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966032,0.001315907,0.0007038794,0.0001661625,0.0001249757,0.0005255342,0.00005385606,0.00002186244,0.0004846174],"genre_scores_gemma":[0.9986758,0.0004045246,0.000312065,0.00003360885,0.00009318644,0.00001693517,0.00001396003,0.00004206062,0.000407893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004534725,"threshold_uncertainty_score":0.722989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01578124102375419,"score_gpt":0.3518000232484164,"score_spread":0.3360187822246622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}