{"id":"W4395464662","doi":"10.1021/acsptsci.4c00014","title":"Enantiomeric Agonists of the Type 2 Cannabinoid Receptor Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit Hyperactive Microglia <i>In Vitro</i>","year":2024,"lang":"en","type":"article","venue":"ACS Pharmacology & Translational Science","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Microglia; Inflammation; Agonist; Proliferative vitreoretinopathy; Cannabinoid receptor type 2; Retinal; Cannabinoid; Pharmacology; Biology; Receptor; Cell biology; Cannabinoid receptor; Immunology; Medicine; Internal medicine; Retinal detachment; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006369203,0.00014874,0.0002155012,0.0002655469,0.0002537735,0.00004043801,0.0001992101,0.00006297123,0.0001216847],"category_scores_gemma":[0.00006400156,0.0001073118,0.00005768253,0.001756932,0.001719735,0.0002494171,0.00007285728,0.0004885145,0.000006722058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001409762,"about_ca_system_score_gemma":0.001496117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005386147,"about_ca_topic_score_gemma":0.000006528224,"domain_scores_codex":[0.9981928,0.0001139263,0.0002826986,0.0004877748,0.0005375118,0.0003852997],"domain_scores_gemma":[0.9993497,0.00003960824,0.00005721828,0.0001189156,0.0002996648,0.0001349298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007907929,0.00009423674,0.002763289,0.0001129809,0.0000206751,0.00003635158,0.001430087,0.00001424478,0.9926969,0.0001393395,0.0007745666,0.00112649],"study_design_scores_gemma":[0.0007541386,0.0001121823,0.09461824,0.00007254977,0.00004354983,0.00013785,0.0001008488,0.0003933134,0.9011659,0.0000564748,0.002441572,0.0001033983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974709,0.0009971656,0.000002037458,0.02262451,0.0004156498,0.0006252515,0.00004995652,0.00001901906,0.0005574106],"genre_scores_gemma":[0.9981495,0.0001127086,0.0001482287,0.0002603721,0.000133406,0.00005252584,0.000009191328,0.00001368718,0.001120412],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09185495,"threshold_uncertainty_score":0.6336435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01069899091897135,"score_gpt":0.3159965741710823,"score_spread":0.305297583252111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}