{"id":"W4395469070","doi":"10.1002/dad2.12589","title":"Aβ oligomers peak in early stages of Alzheimer's disease preceding tau pathology","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Helmholtz Association; National Institute on Aging; Deutsche Forschungsgemeinschaft; Weston Brain Institute; ALS Association; Alzheimer's Association; Michael J. Fox Foundation for Parkinson's Research","keywords":"Tau pathology; Alzheimer's disease; Pathology; Disease; Medicine; Neuroscience; Psychology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002036333,0.0003446474,0.000283671,0.0007780956,0.0003462972,0.0005778078,0.0001651034,0.0003932272,0.002209743],"category_scores_gemma":[0.0004164173,0.0001724969,0.0001836858,0.0004391356,0.0001780296,0.000317212,0.000242813,0.0002711621,0.0004258596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001907555,"about_ca_system_score_gemma":0.0001907755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001541112,"about_ca_topic_score_gemma":0.001926821,"domain_scores_codex":[0.9999255,0.0000089619,0.0000074777,0.00002954429,0.00001629617,0.00001210755],"domain_scores_gemma":[0.9996723,0.00003585764,0.0001644071,0.0000152339,0.00005762728,0.00005448564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001831416,0.0002530932,0.8774924,0.0001420789,0.00009383391,0.000941283,0.0006084373,0.00008612309,0.1007303,0.000166443,0.0003204679,0.017334],"study_design_scores_gemma":[0.00001094906,0.0003344872,0.9924636,0.00001420918,0.00003055316,0.0009339549,0.0001634251,0.00007437064,0.005257421,0.0002132341,0.0004983801,0.000005559774],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984185,0.0005493318,0.0002283136,0.00001744418,0.000004466836,0.000008466877,0.0002162634,0.000012958,0.0005442942],"genre_scores_gemma":[0.9984067,0.0002738862,0.0004394065,0.00001737167,0.000007923994,0.000008955767,0.0002485682,0.000003346602,0.0005937793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002209743,"threshold_uncertainty_score":0.007392347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03990552758957604,"score_gpt":0.3628162293288991,"score_spread":0.3229107017393231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}