{"id":"W4395667431","doi":"10.7554/elife.96868.1.sa2","title":"eLife Assessment: Thymic dendritic cell-derived IL-27p28 promotes the establishment of functional bias against IFN-γ production in newly generated CD4+ T cells through STAT1-related epigenetic mechanisms","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Key Research and Development Program of China; Jinan University","keywords":"Epigenetics; Biology; STAT1; Dendritic cell; Immunology; Interferon; Cell biology; Computational biology; Genetics; Gene; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0003529756,0.0004058977,0.0004572405,0.0007677342,0.0004046828,0.0009674287,0.0003229595,0.0005743571,0.01154302],"category_scores_gemma":[0.0002496854,0.0002865766,0.0002350794,0.0004279147,0.0003446002,0.0003091679,0.0007988487,0.001305706,0.004620143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004654106,"about_ca_system_score_gemma":0.0004864756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000589758,"about_ca_topic_score_gemma":0.001549057,"domain_scores_codex":[0.9993445,0.00002562615,0.00003333317,0.0001769368,0.0002799207,0.0001395586],"domain_scores_gemma":[0.9997216,0.00002800585,0.00006703528,0.00001929845,0.00007849702,0.00008553615],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00033044,0.00004000183,0.001576071,0.0001216557,0.00001310745,0.000154918,0.00005250936,0.0001495617,0.9880705,0.0002716006,0.001182238,0.008037415],"study_design_scores_gemma":[0.00005757643,0.0001690877,0.0208506,0.00003801235,0.00003216512,0.0005186254,0.0002325423,0.002752929,0.9554448,0.0003078171,0.01958384,0.00001204597],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.8999255,0.0055668,0.04623926,0.001902195,0.0006671319,0.000195586,0.01341054,0.002501395,0.02959159],"genre_scores_gemma":[0.9062934,0.002944282,0.03126345,0.0007665136,0.0002106238,0.0002524636,0.01089975,0.0004022544,0.04696723],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.999647,"threshold_uncertainty_score":0.03861523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05219735980359225,"score_gpt":0.309903152486907,"score_spread":0.2577057926833147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}