{"id":"W4395676789","doi":"10.1038/s41467-024-47399-x","title":"Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; School of Medicine, Vanderbilt University; National Cancer Institute; U.S. Department of Health and Human Services; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Vanderbilt University; World Health Organization","keywords":"Colorectal cancer; Gene; Genetics; Biology; Computational biology; East Asia; Cancer; Geography; China","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007467595,0.0003395728,0.0005528,0.001081517,0.0005817711,0.0003987646,0.0003190633,0.0002229231,0.002438559],"category_scores_gemma":[0.00139542,0.0002055297,0.000736205,0.001275484,0.0002797151,0.0001295367,0.0006465011,0.0003657349,0.0003640873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001752997,"about_ca_system_score_gemma":0.0003253701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007801856,"about_ca_topic_score_gemma":0.01406251,"domain_scores_codex":[0.9995767,0.00005330871,0.00003752411,0.0002091729,0.00005862756,0.00006462632],"domain_scores_gemma":[0.999404,0.0002136937,0.00009039742,0.0001299447,0.00007286137,0.00008907125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007386371,0.000103831,0.6816151,0.0001872796,0.0008403544,0.001734575,0.0009188123,0.0009907717,0.2698855,0.000552981,0.000720032,0.04171219],"study_design_scores_gemma":[0.00004243663,0.0001238929,0.9885549,0.00001526001,0.0003483391,0.001118701,0.0001504661,0.0009156401,0.005475806,0.000216922,0.003019793,0.00001791875],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948134,0.0003251199,0.002811778,0.00004072777,0.000006632129,0.00002553596,0.001256185,0.00003150607,0.0006890923],"genre_scores_gemma":[0.9936934,0.0002578988,0.003165432,0.00005551513,0.000007613567,0.00002855141,0.002060403,0.00002082397,0.0007104392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007801856,"threshold_uncertainty_score":0.01551288,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04856379299582173,"score_gpt":0.3631177089768382,"score_spread":0.3145539159810165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}