{"id":"W4395676808","doi":"10.1136/gutjnl-2023-329807","title":"Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC","year":2024,"lang":"en","type":"article","venue":"Gut","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; National Cancer Institute; Fondazione Nadia Valsecchi; Government of Ontario; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi; Deutsche Forschungsgemeinschaft","keywords":"SEMA3A; Axon guidance; Phenotype; Basal (medicine); Pancreatic ductal adenocarcinoma; Neuroscience; Axon; Biology; Semaphorin; Pancreatic cancer; Medicine; Cancer; Internal medicine; Endocrinology; Receptor; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008312773,0.0001994944,0.0002359661,0.000271182,0.0002225256,0.0005250843,0.00007924014,0.0002057713,0.001458705],"category_scores_gemma":[0.00009738035,0.0001326237,0.0002691967,0.0002059646,0.0001849483,0.0001206209,0.0002832173,0.0006378499,0.0005453019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000254022,"about_ca_system_score_gemma":0.0002716473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009802618,"about_ca_topic_score_gemma":0.001393517,"domain_scores_codex":[0.9998876,0.000009288648,0.000007090381,0.00002506488,0.00004461677,0.0000264945],"domain_scores_gemma":[0.9998722,0.00001397586,0.00003092261,0.00001105706,0.00001871333,0.0000531487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008273177,0.00001505508,0.002066129,0.0000373999,0.000006638007,0.0001123803,0.000014909,0.00006699075,0.9965349,0.00004513083,0.00008653025,0.0009311545],"study_design_scores_gemma":[0.00003250638,0.0004258473,0.1505743,0.00003225351,0.00005514471,0.001823215,0.0002959915,0.002848464,0.8325232,0.000281608,0.01109128,0.00001613421],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946415,0.001010029,0.001852906,0.00008962821,0.00001270363,0.00001850442,0.0008814223,0.0002337161,0.001259563],"genre_scores_gemma":[0.9945846,0.0006547336,0.001511614,0.00007699153,0.000007344527,0.0000292576,0.0009528412,0.00003510929,0.002147495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001458705,"threshold_uncertainty_score":0.004879832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03510626124522272,"score_gpt":0.2864408489262515,"score_spread":0.2513345876810288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}