{"id":"W4395683738","doi":"10.3390/cells13090752","title":"Single-Cell RNA Sequencing Reveals Cardiac Fibroblast-Specific Transcriptomic Changes in Dilated Cardiomyopathy","year":2024,"lang":"en","type":"article","venue":"Cells","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University Belfast; Queen's University; Heart Research UK; British Heart Foundation","keywords":"Transcriptome; Dilated cardiomyopathy; Fibroblast; Biology; Population; Cell; RNA-Seq; RNA; Single-cell analysis; Gene expression; Gene; Cardiomyopathy; Cell type; Computational biology; Heart failure; Bioinformatics; Medicine; Genetics; Internal medicine; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002957208,0.0003322274,0.0003644778,0.0001625262,0.00006072901,0.0001174572,0.0002446733,0.000307536,0.00004262201],"category_scores_gemma":[0.000006412481,0.0003389775,0.0002640194,0.0002991583,0.00008268133,0.000009973047,0.00004049727,0.000255578,0.00006409555],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001227672,"about_ca_system_score_gemma":0.00008905367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005227378,"about_ca_topic_score_gemma":0.00005564728,"domain_scores_codex":[0.9981315,0.0001258185,0.000341105,0.0007093606,0.0001746401,0.0005175483],"domain_scores_gemma":[0.999345,0.00002910822,0.00004167648,0.0004112864,0.00004616036,0.0001267754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005318469,0.00004402435,0.0001615769,0.0001943716,0.00004012113,0.00004955084,0.0004516244,0.0001729454,0.9936205,0.00001228519,0.002485185,0.002714613],"study_design_scores_gemma":[0.0003517502,0.0002122124,0.0000689757,0.0001785826,0.0000285327,0.000006419675,0.0001219336,0.0001431533,0.9286183,0.00003293761,0.06984932,0.0003879276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798701,0.01291104,0.0007678529,0.0000985146,0.001608253,0.0003604724,0.0001080701,0.0000847726,0.00419096],"genre_scores_gemma":[0.9952686,0.001497267,0.0003373737,0.0001211422,0.0005957508,0.00002618377,0.0001369694,0.00009150478,0.001925227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06736413,"threshold_uncertainty_score":0.9999062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01765183631205618,"score_gpt":0.210171134972077,"score_spread":0.1925192986600208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}