{"id":"W4395690671","doi":"10.1177/17474930241253702","title":"A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial","year":2024,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Health Sciences Centre; University of Toronto; University of British Columbia; University of Alberta; University of Calgary; Sunnybrook Health Science Centre; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Tenecteplase; Randomized controlled trial; Stroke (engine); Clinical trial; Ischemic stroke; Occlusion; Internal medicine; Thrombolysis; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0203631,0.004075546,0.007621469,0.0008990262,0.0008222081,0.002992994,0.001825364,0.004852913,0.00764055],"category_scores_gemma":[0.02373195,0.001237041,0.006366767,0.0007390818,0.002140918,0.003082893,0.001408709,0.003355605,0.001129134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001273947,"about_ca_system_score_gemma":0.001795783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007120598,"about_ca_topic_score_gemma":0.001052109,"domain_scores_codex":[0.9825026,0.01388404,0.0009459674,0.001547937,0.0005373713,0.0005820329],"domain_scores_gemma":[0.9908958,0.004613781,0.001931048,0.0008805316,0.0007271694,0.0009515397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9884946,0.001567719,0.000333288,0.001272993,0.003688168,0.00003639642,0.00003487481,0.0002822457,0.0003772293,0.000281584,0.0004421986,0.003188759],"study_design_scores_gemma":[0.9845548,0.01257293,0.0002416982,0.0000652229,0.001421524,0.00001166165,0.00000988121,0.000447547,0.0000615621,0.0002742668,0.0003261064,0.00001267449],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.8131513,0.02931463,0.01286547,0.006995963,0.0111421,0.1151914,0.003779177,0.0006854319,0.006874435],"genre_scores_gemma":[0.8514572,0.004790063,0.01530135,0.005134911,0.003565704,0.1134857,0.002196894,0.00008299755,0.003985139],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.0203631,"threshold_uncertainty_score":0.1076916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04396957127619012,"score_gpt":0.3789338203507059,"score_spread":0.3349642490745158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}