{"id":"W4395690671","doi":"10.1177/17474930241253702","title":"A Randomized Controlled Trial of Tenecteplase Versus Standard of Care for Minor Ischemic Stroke with Proven Occlusion (TEMPO-2): Rational and design of a multicenter, randomized open-label clinical trial","year":2024,"lang":"en","type":"article","venue":"International Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Health Sciences Centre; University of Toronto; University of British Columbia; University of Alberta; University of Calgary; Sunnybrook Health Science Centre; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Tenecteplase; Randomized controlled trial; Stroke (engine); Clinical trial; Ischemic stroke; Occlusion; Internal medicine; Thrombolysis; Ischemia; Myocardial infarction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00480664,0.0002635764,0.003538478,0.0004427414,0.00002650242,0.00005551483,0.0004088468,0.0001308105,0.00004374978],"category_scores_gemma":[0.005619455,0.00016524,0.0008802323,0.00007415173,0.0004049937,0.0002219322,0.0001705436,0.0002841663,2.63469e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378945,"about_ca_system_score_gemma":0.00101215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001439548,"about_ca_topic_score_gemma":0.000003123926,"domain_scores_codex":[0.9946765,0.0004721797,0.003068899,0.0002854474,0.0013346,0.000162412],"domain_scores_gemma":[0.9878316,0.00745634,0.002343358,0.000170978,0.002077607,0.0001200997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9748839,0.0009448269,0.00002145017,0.0002239732,0.010629,0.00005543411,0.0003522002,0.00003127331,0.01007188,0.0001674042,0.001387982,0.001230723],"study_design_scores_gemma":[0.9638659,0.01336739,0.000001343455,0.001088924,0.003967265,0.00003487957,0.0003402795,0.00455638,0.01209947,0.00001319861,0.0005493308,0.0001156338],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385347,0.001454882,0.03712996,0.0009099335,0.002785041,0.01783588,0.0004952668,0.00001121447,0.0008431668],"genre_scores_gemma":[0.9643269,0.0004943055,0.03350921,0.00003608358,0.0007077326,0.0003333482,0.00004503789,0.00003257199,0.0005148611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0257922,"threshold_uncertainty_score":0.673829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04396957127619012,"score_gpt":0.3789338203507059,"score_spread":0.3349642490745158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}