{"id":"W4395696997","doi":"10.1016/j.bpsc.2024.04.008","title":"Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry Cognitive Neuroscience and Neuroimaging","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; McMaster University; Kingston General Hospital; Providence Health Care; St Joseph's Health Centre; University of British Columbia; St. Joseph’s Healthcare Hamilton; Hospital for Sick Children; University of Calgary; Centre for Global Health Research; University of Toronto","funders":"Janssen Canada; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute on Aging; NIHR Cambridge Biomedical Research Centre; National Social Science Fund of China; National Medical Research Council; European Commission; Department of Psychiatry, University of Toronto; Knut och Alice Wallenbergs Stiftelse; Canadian Institutes of Health Research; National Institute on Alcohol Abuse and Alcoholism; McKnight Foundation; Pfizer; Avid Radiopharmaceuticals; National Institute on Deafness and Other Communication Disorders; Mitacs; Vetenskapsrådet; Allergan; Agence Régionale de Santé Île-de-France; Institut National de la Santé et de la Recherche Médicale; H. Lundbeck A/S; Agencia Nacional de Investigación y Desarrollo; National University Health System; Emerson Collective; Junta de Andalucía; Government of the United Kingdom; Canada First Research Excellence Fund; China Postdoctoral Science Foundation; Beijing Municipal Science and Technology Commission; Conseil Régional Aquitaine; Singapore Institute for Clinical Sciences; National Heart, Lung, and Blood Institute; Max-Planck-Gesellschaft; Vancouver Coastal Health Research Institute; Université de Bordeaux; Région Normandie; European Regional Development Fund; Jane ja Aatos Erkon Säätiö; University of Toronto; Ontario Mental Health Foundation; Fondazione Cariplo; National Natural Science Foundation of China; Government of Ontario; Biogen; Vistagen Therapeutics; Wellcome Trust; Agence Nationale de la Recherche; National Research Foundation Singapore; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; National Research Foundation; U.S. Department of Defense; Cancer Research UK; National University of Singapore; Sanofi; Eisai; Bill and Melinda Gates Foundation; Lister Institute of Preventive Medicine; University of Oxford; Alzheimerfonden; Indian Council of Medical Research; Beijing Normal University; National Institute of Biomedical Imaging and Bioengineering; Department of Health and Social Care; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Guarantors of Brain; National Health and Medical Research Council; Association France Alzheimer; Compute Canada; Fondation Vaincre Alzheimer; Emil Aaltosen Säätiö; U.S. Department of Veterans Affairs; Suomen Lääketieteen Säätiö; GW Pharmaceuticals; National Science Foundation; Temple University; Genentech; American Academy of Neurology; Fondation Brain Canada; Sunovion; Medical Research Council; Servier; Institut National Du Cancer; National Alliance for Research on Schizophrenia and Depression; Bristol-Myers Squibb; Canadian Network for Mood and Anxiety Treatments; Freistaat Sachsen; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; National Institutes of Health; Children's Hospital Foundation; Signe ja Ane Gyllenbergin Säätiö; GlaxoSmithKline; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Brain and Behavior Research Foundation; Ontario Brain Institute; UK Research and Innovation","keywords":"Major depressive disorder; Neurocognitive; Psychology; Depression (economics); Working memory; Late life depression; Cohort; Effects of sleep deprivation on cognitive performance; Cognition; Clinical psychology; Neuropsychology; Psychiatry; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002626692,0.0002708195,0.0001967411,0.0004444187,0.0002625305,0.0004176771,0.0002713294,0.0003257701,0.0009933468],"category_scores_gemma":[0.001360254,0.0001433461,0.0001864676,0.0003964282,0.0002090883,0.0002145039,0.0002626935,0.000332066,0.00009666914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002280666,"about_ca_system_score_gemma":0.0001575582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003169955,"about_ca_topic_score_gemma":0.004793311,"domain_scores_codex":[0.9999223,0.00001982533,0.0000158341,0.00001571974,0.00001285645,0.00001346506],"domain_scores_gemma":[0.9992182,0.0001409443,0.000436652,0.00004365893,0.00006273925,0.00009767993],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009121136,0.0001766788,0.9901057,0.00003459361,0.0001394641,0.0007630016,0.0001599806,0.0000892766,0.002598849,0.00005460795,0.0001174705,0.004848365],"study_design_scores_gemma":[0.000004328449,0.00004513016,0.9993895,0.00000235404,0.00001486683,0.0002991381,0.00005619571,0.00005544882,0.00005424483,0.00004710761,0.00003014493,0.000001528713],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991935,0.0003322931,0.00003198042,0.0000408337,0.000007606708,0.000002343837,0.00007302366,0.000001574128,0.0003168989],"genre_scores_gemma":[0.9996163,0.0001245317,0.00004451623,0.00001620211,0.00001252638,0.000002096004,0.00007103322,7.837109e-7,0.0001120027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003169955,"threshold_uncertainty_score":0.006303012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03710897150162282,"score_gpt":0.2932574928345285,"score_spread":0.2561485213329057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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