{"id":"W4395697032","doi":"10.1016/j.nicl.2024.103609","title":"Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"NeuroImage Clinical","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; University of Calgary","funders":"National Center for Advancing Translational Sciences; Sanofi Genzyme; Greenwich Biosciences; EMD Serono; Genentech; Eurostars; Amsterdam Neuroscience; ZonMw; TG Therapeutics; Atara Biotherapeutics; Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques; MedDay Pharmaceuticals; Biogen; Celgene; Sanofi; Bristol-Myers Squibb; Patient-Centered Outcomes Research Institute","keywords":"Medicine; Multiple sclerosis; Fluid-attenuated inversion recovery; Atrophy; Audiology; Cognition; Psychology; Magnetic resonance imaging; Neuroscience; Internal medicine; Psychiatry; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003421405,0.0004745277,0.001739985,0.0002827149,0.0001560578,0.00008490513,0.0001679204,0.0002194707,0.000008682317],"category_scores_gemma":[0.01322084,0.0003413943,0.0002536386,0.0009323999,0.0007079768,0.0002077273,0.0004373904,0.001957838,0.000006202105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001346719,"about_ca_system_score_gemma":0.0002223316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006435168,"about_ca_topic_score_gemma":0.006595364,"domain_scores_codex":[0.9934049,0.001791854,0.001672181,0.001599276,0.0008623327,0.0006694721],"domain_scores_gemma":[0.9883286,0.009798109,0.0004972086,0.0005537931,0.0004724667,0.0003498625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004077374,0.0155279,0.9732416,0.0002108346,0.0006737594,0.0005706795,0.001277218,0.000006274509,0.000174405,5.031526e-7,0.00005997051,0.004179432],"study_design_scores_gemma":[0.03723154,0.009597067,0.9350001,0.004377157,0.0003679262,0.00002303489,0.003221853,0.009876747,0.00002178366,9.333322e-7,0.000001873999,0.0002800203],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960297,0.000142238,0.00008103663,0.0003630104,0.0002068998,0.002831449,0.00009011499,0.0001919925,0.00006351064],"genre_scores_gemma":[0.9980655,0.0008906568,0.0005059984,0.0001069772,0.000123024,0.0001365865,0.00002358108,0.0001054874,0.0000421986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03824158,"threshold_uncertainty_score":0.9999038,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1615429132575564,"score_gpt":0.4016964917124442,"score_spread":0.2401535784548878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}