{"id":"W4396216391","doi":"10.1158/2159-8290.cd-23-0428","title":"Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; Center for Cellular Imaging, Washington University; National Institute on Aging; Canadian Institutes of Health Research; Georgia Clinical and Translational Science Alliance; Institute of Clinical and Translational Sciences; National Institutes of Health; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital; National Cancer Institute; Washington University in St. Louis; U.S. Department of Defense","keywords":"Biology; Stromal cell; Cancer research; Pancreatic cancer; Tumor microenvironment; Senescence; Tumor progression; Cancer-Associated Fibroblasts; Immune system; Immunotherapy; Phenotype; Immunosuppression; Cancer; Immunology; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000125169,0.0002954793,0.0005600441,0.0002025912,0.00004231148,0.00007388613,0.0001635056,0.0001147426,0.0001784811],"category_scores_gemma":[0.00005696347,0.0002235797,0.0001449648,0.0006243277,0.0002203054,0.0004852265,0.00006602296,0.000257544,0.000009481503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144591,"about_ca_system_score_gemma":0.000699255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003699627,"about_ca_topic_score_gemma":0.0008894962,"domain_scores_codex":[0.9982566,0.00005475146,0.000411429,0.0005076544,0.0003561742,0.0004134474],"domain_scores_gemma":[0.9991619,0.0001974949,0.00009718303,0.0003781137,0.00005660157,0.0001087062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005069545,0.0001203296,0.8129322,0.002892934,0.0001022171,0.0001912297,0.0008551988,0.00005408697,0.1714904,0.0001922043,0.00100196,0.00966029],"study_design_scores_gemma":[0.000768545,0.0001050372,0.8916629,0.01183279,0.0001758634,0.00004201943,0.0004072836,0.0006814872,0.09282298,0.0001995731,0.000959189,0.0003423081],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578768,0.03988948,0.000118109,0.0006052048,0.0005998068,0.0003315602,0.0002160079,0.00007653257,0.0002865005],"genre_scores_gemma":[0.9909218,0.007256764,0.00006696401,0.00009442387,0.0001628133,0.0001518114,0.00005762813,0.00004544057,0.001242377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07873073,"threshold_uncertainty_score":0.9117316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052488924254222,"score_gpt":0.308417909089454,"score_spread":0.2778930198469118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}