{"id":"W4396216391","doi":"10.1158/2159-8290.cd-23-0428","title":"Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer","year":2024,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":104,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; National Center for Advancing Translational Sciences; National Institute of Biomedical Imaging and Bioengineering; National Institute of Diabetes and Digestive and Kidney Diseases; Center for Cellular Imaging, Washington University; National Institute on Aging; Canadian Institutes of Health Research; Georgia Clinical and Translational Science Alliance; Institute of Clinical and Translational Sciences; National Institutes of Health; Alvin J. Siteman Cancer Center; Foundation for Barnes-Jewish Hospital; National Cancer Institute; Washington University in St. Louis; U.S. Department of Defense","keywords":"Biology; Stromal cell; Cancer research; Pancreatic cancer; Tumor microenvironment; Senescence; Tumor progression; Cancer-Associated Fibroblasts; Immune system; Immunotherapy; Phenotype; Immunosuppression; Cancer; Immunology; Cell biology; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941041,0.0001567798,0.0001606242,0.0004035179,0.0001696688,0.0002418366,0.00006154792,0.0001513772,0.0003616374],"category_scores_gemma":[0.0001057481,0.00008744611,0.0001386562,0.0001524595,0.0001359126,0.000186586,0.0001791502,0.0001897534,0.0001225082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261367,"about_ca_system_score_gemma":0.0001330433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002127427,"about_ca_topic_score_gemma":0.0005140067,"domain_scores_codex":[0.9999353,0.00001179732,0.000007731142,0.0000163761,0.00001452057,0.00001428752],"domain_scores_gemma":[0.9999238,0.000006633462,0.00002848478,0.000008378096,0.0000113516,0.00002135028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000147389,0.00001700542,0.0118791,0.00003717501,0.000007319363,0.0002083752,0.0000911786,0.00006577766,0.9815567,0.0001905128,0.00007736721,0.005722017],"study_design_scores_gemma":[0.00003997541,0.001554302,0.4631902,0.00005996694,0.00007889282,0.01124815,0.0006585594,0.002338539,0.5039856,0.0007962169,0.01602338,0.00002620779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946849,0.003383609,0.001084133,0.0000690451,0.000007012493,0.00001390987,0.00008637464,0.00002660456,0.0006445781],"genre_scores_gemma":[0.9969259,0.001549293,0.0006398868,0.00004183102,0.00001555993,0.00001588679,0.0001177545,0.000004749209,0.0006892147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004035179,"threshold_uncertainty_score":0.001209855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03052488924254222,"score_gpt":0.308417909089454,"score_spread":0.2778930198469118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}