{"id":"W4396220164","doi":"10.1021/acs.jproteome.4c00163","title":"Discovery and Verification of Sjögren’s Syndrome Protein Biomarkers in Tears by Targeted LC-MRM","year":2024,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Université du Québec à Montréal","keywords":"Medicine; Tears; Proteases; Lacrimal gland; Cohort; Disease; Internal medicine; Pathology; Gastroenterology; Lacrimal apparatus; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006846299,0.0007366278,0.0004518948,0.001522729,0.0003068688,0.0006023188,0.000238711,0.0006509012,0.0006189555],"category_scores_gemma":[0.0008225266,0.0002415301,0.0005439097,0.0005737276,0.0002892273,0.0003203074,0.0004059293,0.0003644041,0.0003344826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456778,"about_ca_system_score_gemma":0.0002277749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004913503,"about_ca_topic_score_gemma":0.0007179778,"domain_scores_codex":[0.9995308,0.00008399427,0.00005707257,0.0001401898,0.000114874,0.00007306211],"domain_scores_gemma":[0.999679,0.0000676281,0.00008243274,0.00003660705,0.0001008946,0.00003346643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004248463,0.00006410395,0.01074882,0.0001476132,0.00009501755,0.0004632108,0.0001388909,0.0001048852,0.9816098,0.00006617208,0.0001211484,0.006015388],"study_design_scores_gemma":[0.00006931402,0.001081346,0.1162739,0.00008162087,0.0003407837,0.004338893,0.0003336708,0.003583597,0.8679397,0.0002727008,0.005643359,0.00004099957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898028,0.003091066,0.005340213,0.0001112439,0.00005093211,0.00009539004,0.0008127701,0.0001116108,0.0005839075],"genre_scores_gemma":[0.9805742,0.001704622,0.01500972,0.000312254,0.00003344046,0.0001288289,0.001182918,0.00004005258,0.001013939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001522729,"threshold_uncertainty_score":0.003620744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811592672632192,"score_gpt":0.3459946626633448,"score_spread":0.3178787359370229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}