{"id":"W4396220164","doi":"10.1021/acs.jproteome.4c00163","title":"Discovery and Verification of Sjögren’s Syndrome Protein Biomarkers in Tears by Targeted LC-MRM","year":2024,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Ocular Surface and Contact Lens","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Université du Québec à Montréal","keywords":"Medicine; Tears; Proteases; Lacrimal gland; Cohort; Disease; Internal medicine; Pathology; Gastroenterology; Lacrimal apparatus; Immunology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00254425,0.00009166844,0.0002994358,0.0006959971,0.00003059473,0.00006856106,0.0001110711,0.0001010245,0.00004034846],"category_scores_gemma":[0.000331289,0.00006918225,0.00008469709,0.0006763585,0.0001228294,0.000365785,0.00004259387,0.0007214854,0.000009759982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001770633,"about_ca_system_score_gemma":0.0004461959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001203857,"about_ca_topic_score_gemma":0.000005559337,"domain_scores_codex":[0.9980729,0.0002148694,0.0004505801,0.0001698307,0.0008287386,0.0002630855],"domain_scores_gemma":[0.9993163,0.00007731721,0.00009162706,0.0001738496,0.0002236529,0.0001172481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005424414,0.0001597573,0.007576306,0.0009003711,0.0002087442,0.0006830621,0.000271522,5.315125e-7,0.9855251,0.00008924205,0.00036761,0.003675282],"study_design_scores_gemma":[0.006542305,0.01011411,0.3057424,0.01463565,0.0001711408,0.001255121,0.00317283,0.001178006,0.6393071,0.001968991,0.01535126,0.0005611363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879539,0.007736082,0.00009325874,0.003163579,0.00004383169,0.0008608322,0.00001047603,0.00000634242,0.0001317111],"genre_scores_gemma":[0.9981779,0.0003851689,0.0005268687,0.000005893338,0.00003313946,0.00002684726,0.000002991023,0.00001950892,0.0008217178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.346218,"threshold_uncertainty_score":0.3134535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02811592672632192,"score_gpt":0.3459946626633448,"score_spread":0.3178787359370229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}