{"id":"W4396222765","doi":"10.1242/jcs.262172","title":"SARS-CoV-2 NSP5 antagonizes MHC II expression by subverting histone deacetylase 2","year":2024,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Robarts Clinical Trials; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Histone deacetylase; Virology; Histone deacetylase 2; Major histocompatibility complex; Cell biology; Histone; Cancer research; Immune system; Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001884142,0.0001530174,0.0002913517,0.0004448351,0.000281917,0.0001564308,0.0004984316,0.00007108428,0.0000186062],"category_scores_gemma":[0.0004675146,0.0001067559,0.0001425047,0.001170629,0.0004287799,0.0006524702,0.0001801952,0.0005955832,0.00005437799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003768177,"about_ca_system_score_gemma":0.001325577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003658985,"about_ca_topic_score_gemma":0.000002303912,"domain_scores_codex":[0.9971315,0.00004202044,0.0004993217,0.0003172903,0.001513498,0.0004963832],"domain_scores_gemma":[0.9989488,0.0001300873,0.0001781218,0.0002439735,0.0003879593,0.0001110328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227416,0.0001369666,0.0003801909,0.0001011566,0.000006327609,0.0004221316,0.0006871087,4.268292e-7,0.9800771,0.00001047326,0.01500195,0.003053379],"study_design_scores_gemma":[0.000534931,0.0004266842,0.00007107528,0.0003746715,0.0000246483,0.0003339793,0.0001265147,0.0007676091,0.853816,0.00004937237,0.1433729,0.0001015509],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880628,0.00546386,0.0005224965,0.0009336177,0.0006053357,0.0001077961,0.000002055333,0.00003482736,0.00426722],"genre_scores_gemma":[0.9930214,0.00005415511,0.0007949697,0.00551472,0.0002841658,0.000001755334,2.317257e-7,0.00001841501,0.000310202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.128371,"threshold_uncertainty_score":0.435338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03434404945480358,"score_gpt":0.374079179108459,"score_spread":0.3397351296536554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}