{"id":"W4396223187","doi":"10.1080/17425247.2024.2347300","title":"Enzyme-responsive mannose-grafted magnetic nanoparticles for breast and liver cancer therapy and tumor-associated macrophage immunomodulation","year":2024,"lang":"en","type":"article","venue":"Expert Opinion on Drug Delivery","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Manitoba","funders":"Shiraz University","keywords":"Tumor microenvironment; Immunotherapy; Mannose receptor; Cancer research; Immune system; Breast cancer; Macrophage; Mannan; Cancer immunotherapy; Chemotherapy; Mannose; Magnetic nanoparticles; Tumor-associated macrophage; Cancer; Medicine; Immunology; Materials science; Chemistry; Nanoparticle; Internal medicine; Nanotechnology; Biochemistry; In vitro; Polysaccharide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002341595,0.0002805959,0.0002687621,0.0001618611,0.0002614684,0.00007962011,0.000120994,0.0001666042,0.0004597592],"category_scores_gemma":[0.000026335,0.0002504658,0.00008202023,0.0001438555,0.0002376585,0.0001704329,0.00007598295,0.000212204,0.00007228164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367974,"about_ca_system_score_gemma":0.00008435487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004346452,"about_ca_topic_score_gemma":0.00002163965,"domain_scores_codex":[0.9985099,0.0002337397,0.0002852555,0.0005087463,0.00006013399,0.0004022079],"domain_scores_gemma":[0.9991353,0.0004314232,0.0000749474,0.000211148,0.0001139621,0.00003319428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001583025,0.0001152016,0.00008938304,0.00003562048,0.000230092,0.00001373028,0.003253769,0.00001183078,0.799768,0.0002009817,0.01784619,0.1768522],"study_design_scores_gemma":[0.006329721,0.001000214,0.03063402,0.0008933665,0.00003545816,0.0002065279,0.001072373,0.001942687,0.7065108,0.000232162,0.2501274,0.001015337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6564903,0.3403739,0.000006724679,0.0005735658,0.001806024,0.0004380571,0.000175936,0.0001098571,0.00002568795],"genre_scores_gemma":[0.9641757,0.03300111,0.00004302519,0.0007130747,0.000103204,0.000252933,0.0001039624,0.00005315272,0.001553813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3076855,"threshold_uncertainty_score":0.9999948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585986010802667,"score_gpt":0.2665208514819116,"score_spread":0.250660991373885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}