{"id":"W4396229502","doi":"10.2196/56067","title":"Effects of Empagliflozin in Type 2 Diabetes With and Without Chronic Kidney Disease and Nondiabetic Chronic Kidney Disease: Protocol for 3 Crossover Randomized Controlled Trials (SiRENA Project)","year":2024,"lang":"en","type":"article","venue":"JMIR Research Protocols","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Empagliflozin; Medicine; Kidney disease; Type 2 diabetes; Randomized controlled trial; Disease; Diabetes mellitus; Crossover study; Clinical trial; Protocol (science); Internal medicine; Alternative medicine; Endocrinology; Pathology; Placebo","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02438639,0.005726111,0.01186068,0.001858205,0.002747037,0.003405063,0.002803875,0.006155454,0.02523554],"category_scores_gemma":[0.02214588,0.002313053,0.00754987,0.002496784,0.002572679,0.002472595,0.001902611,0.005722094,0.00390459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00310322,"about_ca_system_score_gemma":0.007483088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002096285,"about_ca_topic_score_gemma":0.003817786,"domain_scores_codex":[0.9808787,0.01195488,0.002343529,0.001854768,0.001281123,0.00168707],"domain_scores_gemma":[0.9924201,0.001866809,0.002030053,0.0009851557,0.001564104,0.001133775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9701735,0.003695925,0.0004491661,0.006338581,0.003141764,0.00006415622,0.0001264205,0.0007135471,0.001225544,0.00102033,0.004342464,0.008708579],"study_design_scores_gemma":[0.9809803,0.008337075,0.0009457325,0.0005792269,0.001164063,0.00002640489,0.00002703679,0.0009096591,0.0002645002,0.0007024911,0.006029459,0.00003395538],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01204671,0.001496324,0.002968401,0.0004303282,0.0007628532,0.9780468,0.002219255,0.0003191618,0.001710152],"genre_scores_gemma":[0.01015339,0.0004710894,0.004292355,0.0003627541,0.0001027416,0.983395,0.0004486513,0.00001695912,0.0007570225],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02523554,"threshold_uncertainty_score":0.1289691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06193542273497171,"score_gpt":0.4734438179617428,"score_spread":0.4115083952267711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}