{"id":"W4396229642","doi":"10.1021/acs.biomac.4c00117","title":"Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids","year":2024,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"H2020 Marie Skłodowska-Curie Actions; Medical Research Council; European Commission; Department of Health and Social Care; Engineering and Physical Sciences Research Council; UK Regenerative Medicine Platform; National Institute for Health and Care Research; Horizon 2020 Framework Programme; King's College London; Imperial College London; Francis Crick Institute","keywords":"Nucleic acid; Chemistry; Nanotechnology; Biochemical engineering; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001070559,0.0002277183,0.0001784869,0.00008141232,0.00009690777,0.0000962437,0.0002479889,0.0002343732,0.00001569007],"category_scores_gemma":[0.00001802714,0.0001921807,0.0001607788,0.00009509699,0.0001022546,0.00001231096,0.0001232432,0.00008063804,0.000003026201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001327593,"about_ca_system_score_gemma":0.00007533906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001684209,"about_ca_topic_score_gemma":0.00005316703,"domain_scores_codex":[0.9989499,0.00004473518,0.0002197434,0.0004360218,0.0001091344,0.000240444],"domain_scores_gemma":[0.9994253,0.000009093932,0.00004216041,0.0003757685,0.00008831586,0.00005937157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004200592,0.00005690179,0.000142232,0.0002253107,0.0001974893,0.00001159347,0.00008591268,0.00001330247,0.9961821,0.00006275688,0.0003176405,0.002284698],"study_design_scores_gemma":[0.0004169459,0.001846268,0.002777287,0.0001494575,0.00006412953,0.00006616305,0.00005308661,0.0001673764,0.9935094,0.00006202652,0.0006350426,0.0002528794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796456,0.01441053,0.004732783,0.0002663476,0.0002358697,0.0004779648,0.00015085,0.0000362737,0.00004377069],"genre_scores_gemma":[0.9984838,0.0003786264,0.000254704,0.0001126374,0.0002208021,0.00008014393,0.0001196393,0.0000451005,0.0003045049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01883823,"threshold_uncertainty_score":0.78369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582710316621722,"score_gpt":0.249551151052776,"score_spread":0.2337240478865588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}