{"id":"W4396229659","doi":"10.1097/fpc.0000000000000533","title":"Novel variant in Nudix hydrolase 15 gene influences 6-mercaptopurine toxicity in childhood acute lymphoblastic leukemia patients","year":2024,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Thiopurine methyltransferase; Mercaptopurine; Medicine; Pharmacogenetics; Adverse effect; Allele; Genotype; Pharmacology; Internal medicine; Gene; Oncology; Biology; Genetics; Disease; Azathioprine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003240829,0.000364134,0.0004656071,0.0005041053,0.00006362944,0.0000931527,0.000225129,0.000160955,0.00006612261],"category_scores_gemma":[0.00007341889,0.0003375932,0.00008301131,0.000607821,0.0001444128,0.00010421,0.0003020989,0.00042597,0.00005282162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00149181,"about_ca_system_score_gemma":0.001270912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002131268,"about_ca_topic_score_gemma":0.00004719581,"domain_scores_codex":[0.9975004,0.00004483226,0.0006464768,0.0007060093,0.0004231019,0.0006791881],"domain_scores_gemma":[0.9990457,0.0001651096,0.00006385745,0.0002688711,0.00007790541,0.0003785608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001572555,0.002478697,0.06134593,0.0008941492,0.001142595,0.006232813,0.004414826,0.01195487,0.857964,0.0001776282,0.0006621105,0.05115985],"study_design_scores_gemma":[0.0302256,0.001137817,0.3074035,0.0006107849,0.0008198901,0.002318567,0.00009621222,0.5535825,0.09682056,0.0005703774,0.005039122,0.001375021],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955248,0.002213522,0.0005115629,0.0002543795,0.0002940295,0.0007333319,0.0002224906,0.00004461874,0.0002012842],"genre_scores_gemma":[0.9925905,0.004250486,0.002020769,0.0006250093,0.0002209987,0.00005160089,0.00008160623,0.00007097219,0.00008800092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7611434,"threshold_uncertainty_score":0.9999076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01154802643354451,"score_gpt":0.2776264064011444,"score_spread":0.2660783799675999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}