{"id":"W4396229714","doi":"10.1016/j.virusres.2024.199381","title":"The glycosylation sites in RBD of spike protein attenuate the immunogenicity of PEDV AH2012/12","year":2024,"lang":"en","type":"article","venue":"Virus Research","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Jiangsu Agricultural Science and Technology Innovation Fund; Government of Jiangsu Province; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Jiangsu Academy of Agricultural Sciences","keywords":"Immunogenicity; Biology; Glycosylation; Spike Protein; Spike (software development); Virology; Computational biology; Coronavirus disease 2019 (COVID-19); Genetics; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00199336,0.00006792137,0.0001014288,0.00002988057,0.0004177364,0.00005623325,0.0003061327,0.0000465137,0.0001015124],"category_scores_gemma":[0.0003806181,0.00001831585,0.00007211228,0.0009069853,0.0004068738,0.00007171706,0.0002376008,0.0002882469,0.00006707677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004021881,"about_ca_system_score_gemma":0.00001876448,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.007198834,"about_ca_topic_score_gemma":0.01808361,"domain_scores_codex":[0.9986224,0.0003201852,0.0002306456,0.000159857,0.0004119042,0.0002550721],"domain_scores_gemma":[0.9987389,0.0009629373,0.00003824326,0.00008349981,0.0001596427,0.00001680697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009297242,0.00004734861,0.008580175,0.0000159186,0.00002096552,0.0000010735,0.0002459831,0.000003001941,0.9500964,0.002695346,0.0003406564,0.03786022],"study_design_scores_gemma":[0.0001014917,0.0007714191,0.726728,0.0001206752,0.000007011859,0.000002090218,0.001532976,0.0004348493,0.2150981,0.006292636,0.04877849,0.0001323399],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932199,0.002864866,0.000001037845,0.001249195,0.00002831248,0.000425741,0.00003111467,0.00001597798,0.002163816],"genre_scores_gemma":[0.9986634,0.000707924,0.000005820329,0.000004642276,0.00007454403,0.00006649792,0.000002958093,9.222359e-7,0.0004732754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7349983,"threshold_uncertainty_score":0.9998338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1379711188651149,"score_gpt":0.3649390688572934,"score_spread":0.2269679499921785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}