{"id":"W4396229870","doi":"10.1002/cmdc.202400175","title":"Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin","year":2024,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacitracin; Colistin; Sulfonamide; Niclosamide; Antibacterial activity; Chemistry; Microbiology; Antibiotics; Biology; Stereochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230688,0.0001525074,0.0002546313,0.00003777622,0.00002353891,0.00002105881,0.0001021257,0.0001181235,0.00002371924],"category_scores_gemma":[0.00007462828,0.0001313879,0.00009418274,0.00007982184,0.0002102339,0.00001075178,0.00009273183,0.00006303841,0.00000114804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005565806,"about_ca_system_score_gemma":0.00005202423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004166339,"about_ca_topic_score_gemma":0.00002240332,"domain_scores_codex":[0.9992348,0.00002145517,0.000208915,0.0002800718,0.00009615101,0.0001585976],"domain_scores_gemma":[0.9995714,0.00004943274,0.00008783326,0.0001998863,0.00004736965,0.00004403409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049682,0.00006819319,0.0003102972,0.0004196462,0.0000534776,0.000001485297,0.00007170099,4.597254e-7,0.9858192,0.0001676913,0.0003359097,0.012647],"study_design_scores_gemma":[0.0001372318,0.0001103521,0.002023601,0.0001100497,0.00002414609,0.000007644902,0.00004627844,0.00004142347,0.991064,0.0001075706,0.006186063,0.0001416529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955784,0.002674401,0.0001481281,0.0001137271,0.0002009061,0.00007998362,0.0001119026,0.00001180799,0.001080744],"genre_scores_gemma":[0.9986925,0.0003689204,0.0002074633,0.00001777711,0.0003062255,0.000005894088,0.0000202923,0.00001882285,0.0003620986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01250535,"threshold_uncertainty_score":0.5357844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055933758190601,"score_gpt":0.2606259219338317,"score_spread":0.2500665843519257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}