{"id":"W4396229870","doi":"10.1002/cmdc.202400175","title":"Sulfonamide Bioisosteres of Niclosamide Enhance Antibacterial Activity of Colistin and Bacitracin","year":2024,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Phenothiazines and Benzothiazines Synthesis and Activities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacitracin; Colistin; Sulfonamide; Niclosamide; Antibacterial activity; Chemistry; Microbiology; Antibiotics; Biology; Stereochemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001055442,0.0002483577,0.0001198177,0.0001485362,0.00006873554,0.0001157973,0.0001513656,0.0001679608,0.00120594],"category_scores_gemma":[0.0001139262,0.00009444154,0.0001254937,0.00008661686,0.0001672094,0.0001483219,0.0001459444,0.000235121,0.00018758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334303,"about_ca_system_score_gemma":0.0002457987,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005506449,"about_ca_topic_score_gemma":0.001071995,"domain_scores_codex":[0.9999349,0.00001741086,0.000005284995,0.000009424721,0.00001676463,0.000016181],"domain_scores_gemma":[0.9999443,0.000006798984,0.00001989255,0.000005983637,0.000008045975,0.00001500233],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001297544,0.00002646168,0.00008371438,0.00002953801,0.000004052274,0.00004550995,0.00001113744,0.0001618191,0.9972829,0.0002399829,0.00002456771,0.001960706],"study_design_scores_gemma":[0.00001959103,0.0004448047,0.0005306703,0.00000366522,0.000006450045,0.00008043116,0.00000799119,0.0003962541,0.9965349,0.00002538374,0.001947148,0.000002682496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930664,0.001321487,0.002374883,0.00009337805,0.00002138051,0.0000411,0.00009834417,0.00003772095,0.002945278],"genre_scores_gemma":[0.9938863,0.0007547862,0.002911377,0.00003457682,0.000008753294,0.00002272682,0.0001057702,0.000007004586,0.002268743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00120594,"threshold_uncertainty_score":0.004034281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055933758190601,"score_gpt":0.2606259219338317,"score_spread":0.2500665843519257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}