{"id":"W4396231942","doi":"10.1093/haschl/qxae053","title":"Paving the path for implementation of clinical genomic sequencing globally: Are we ready?","year":2024,"lang":"en","type":"article","venue":"Health Affairs Scholar","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; SickKids Foundation; University of Toronto; Hospital for Sick Children; University of British Columbia; Alberta Children's Hospital; Canadian Centre for Applied Research in Cancer Control; Institute for Clinical Evaluative Sciences; University of Calgary","funders":"National Human Genome Research Institute; EuroQol Research Foundation","keywords":"Context (archaeology); Health care; Resource (disambiguation); Genomic sequencing; Data science; Management science; Knowledge management; Medicine; Computer science; Economic growth; Engineering; Economics; Geography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1452834,0.001046049,0.002126209,0.00184297,0.004451607,0.01916895,0.00583361,0.0361867,0.0153466],"category_scores_gemma":[0.3192291,0.001152083,0.002675719,0.002124456,0.02309125,0.04537243,0.01409546,0.05252376,0.003114752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01114964,"about_ca_system_score_gemma":0.08799838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01372994,"about_ca_topic_score_gemma":0.01879226,"domain_scores_codex":[0.8953489,0.07022142,0.007846148,0.005874251,0.01390273,0.006806558],"domain_scores_gemma":[0.5490221,0.3552256,0.01531183,0.01021217,0.0423268,0.02790145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002710806,0.0001670822,0.002527239,0.003694649,0.0001784607,0.0007322399,0.006962819,0.00157964,0.0005965667,0.1951723,0.6053197,0.1827981],"study_design_scores_gemma":[0.0002127581,0.0002582672,0.002598408,0.01275987,0.0001333758,0.000397556,0.01241817,0.00108292,0.0008489166,0.2657891,0.7031927,0.0003080157],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.000179707,0.003173796,0.001242966,0.9917721,0.003030868,0.00001434746,0.00001952362,0.00001580968,0.0005507829],"genre_scores_gemma":[0.01646961,0.02321577,0.01208664,0.9313238,0.01484465,0.0002368007,0.0001598144,0.0001618933,0.001501113],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1452834,"threshold_uncertainty_score":0.7683412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05730496727823579,"score_gpt":0.4094343446142362,"score_spread":0.3521293773360004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}