{"id":"W4396235154","doi":"10.1016/j.biopsych.2024.02.270","title":"35. Investigating Endocannabinoid Metabolism in Opioid Treated Chronic Pain Patients With and Without Opioid Use Disorder: A PET Study With Fatty Acid Amide Hydrolase Radioligand [C-11]CURB","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Diet and metabolism studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Fatty acid amide hydrolase; Endocannabinoid system; Radioligand; Opioid; Metabolism; Chronic pain; Medicine; Fatty acid metabolism; Fatty acid; Chemistry; Pharmacology; Internal medicine; Endocrinology; Cannabinoid receptor; Psychiatry; Biochemistry; Receptor; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004168295,0.0002827432,0.0003371061,0.0002526228,0.0006665575,0.0004237116,0.0001848462,0.0006246254,0.003193012],"category_scores_gemma":[0.0005346164,0.0002329057,0.000382295,0.0002638109,0.000252428,0.0003550554,0.0001655296,0.0003285423,0.0003719862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002793978,"about_ca_system_score_gemma":0.0003182519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006541348,"about_ca_topic_score_gemma":0.01067623,"domain_scores_codex":[0.999893,0.00003355699,0.00000937631,0.00002145567,0.00001164853,0.00003092978],"domain_scores_gemma":[0.9998387,0.00005155137,0.00001759311,0.00001870246,0.00002229648,0.00005107942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05526736,0.003440168,0.6909271,0.0004201815,0.001026862,0.005236387,0.0009797653,0.0003761364,0.1754111,0.0004070259,0.00106013,0.06544793],"study_design_scores_gemma":[0.002204851,0.01292487,0.967618,0.00002561149,0.0008024233,0.002619528,0.0004081603,0.0003912982,0.01002361,0.0001485117,0.002808858,0.00002423668],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962838,0.001396652,0.0002048806,0.0001333806,0.00002147517,0.00006519055,0.0001658707,0.00000682684,0.001721858],"genre_scores_gemma":[0.9960521,0.0006768768,0.0006802882,0.0006039267,0.00002811466,0.00006038549,0.0002418875,0.000008118114,0.001648346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006541348,"threshold_uncertainty_score":0.01300651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490760012110399,"score_gpt":0.2544979723388371,"score_spread":0.2395903722177331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}