{"id":"W4396236939","doi":"10.1016/j.biopsych.2024.02.012","title":"Astrocytic Cannabinoid Receptor 1 Promotes Resilience by Dampening Stress-Induced Blood-Brain Barrier Alterations and Inflammation","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Irish Research Council; Science Foundation Ireland","keywords":"Inflammation; Blood–brain barrier; Cannabinoid receptor; Resilience (materials science); Neuroscience; Neuroinflammation; Medicine; Receptor; Biology; Immunology; Internal medicine; Central nervous system; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000121129,0.0004732492,0.0004883368,0.0003406264,0.0005101573,0.0004385152,0.0002462528,0.0003737554,0.002882057],"category_scores_gemma":[0.0002353029,0.0002158555,0.000528968,0.0001652708,0.0003568927,0.0003138432,0.0004613195,0.001062238,0.0004918691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004694135,"about_ca_system_score_gemma":0.0007557865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002362624,"about_ca_topic_score_gemma":0.00688308,"domain_scores_codex":[0.9998363,0.00001992944,0.00000809812,0.00002489943,0.00002959199,0.00008117548],"domain_scores_gemma":[0.999877,0.000005513201,0.0000372534,0.00001041853,0.00002630713,0.00004345572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005812152,0.0003923831,0.001477194,0.0005350502,0.0001504067,0.0003918218,0.0001272307,0.0002950659,0.9692114,0.001069955,0.001376293,0.01916104],"study_design_scores_gemma":[0.0005462695,0.004402008,0.1009006,0.0001922059,0.0007579645,0.001121414,0.001186344,0.003066053,0.8651256,0.003096918,0.01950982,0.00009472429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805187,0.00996082,0.00277254,0.001220095,0.00056369,0.00006233458,0.0005623362,0.0002582766,0.004081115],"genre_scores_gemma":[0.9902705,0.004179204,0.0009643625,0.000210527,0.00007382795,0.00005526243,0.0002287726,0.00002475437,0.003992958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002882057,"threshold_uncertainty_score":0.009641469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662535374934,"score_gpt":0.2979981508358867,"score_spread":0.2813727970865467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}