{"id":"W4396237115","doi":"10.1016/j.biopsych.2024.02.477","title":"242. Adjunctive Treatment With Semaglutide for Cognitive Dysfunction in Major Depressive Disorder: Reduction in Depression Scores Associated With Increased HbA1c Function and Glucose Levels","year":2024,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Cardiac Health and Mental Health","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University Health Network; Toronto Western Hospital","funders":"","keywords":"Depression (economics); Semaglutide; Major depressive disorder; Medicine; Clinical psychology; Cognition; Adjunctive treatment; Psychology; Depressive symptoms; Psychiatry; Internal medicine; Diabetes mellitus; Endocrinology; Type 2 diabetes","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002633313,0.0002608402,0.000428961,0.0002188761,0.000118714,0.00001661781,0.00001862421,0.0002440254,0.00001308051],"category_scores_gemma":[0.00008699841,0.0001522072,0.00006774555,0.0003921399,0.0001024082,0.00008898135,0.00001310493,0.0002519764,0.000001956347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004432095,"about_ca_system_score_gemma":0.000386181,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000843583,"about_ca_topic_score_gemma":0.002534425,"domain_scores_codex":[0.9983441,0.0001698352,0.0003138906,0.0006410193,0.0001469312,0.0003841827],"domain_scores_gemma":[0.9992791,0.0002511591,0.00009680852,0.00009551211,0.00006629431,0.0002111311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02366948,0.001007582,0.9337729,0.0003038291,0.0001173437,0.00002162975,0.0001630129,0.000006283722,0.0007088472,0.00007320855,0.00007479736,0.04008105],"study_design_scores_gemma":[0.01473712,0.009452455,0.9713027,0.002073798,0.0002279534,0.00008513605,0.00093135,0.0002260452,0.0002109801,0.0004538556,0.0001043478,0.0001942786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990676,0.004551275,0.0006676835,0.0004922936,0.0004619377,0.002708291,0.0001957783,0.0001036838,0.0001430666],"genre_scores_gemma":[0.9975039,0.000291221,0.0002545423,0.0003556268,0.0002087357,0.0007390654,0.0005885299,0.0000246439,0.00003369962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03988677,"threshold_uncertainty_score":0.6206828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02520677738331082,"score_gpt":0.3076205212629183,"score_spread":0.2824137438796074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}